Gene description for GP1BA
Gene name glycoprotein Ib (platelet), alpha polypeptide
Gene symbol GP1BA
Other names/aliases BDPLT1
BDPLT3
BSS
CD42B
CD42b-alpha
DBPLT3
GP1B
GPIbA
VWDP
Species Homo sapiens
 Database cross references - GP1BA
ExoCarta ExoCarta_2811
Vesiclepedia VP_2811
Entrez Gene 2811
HGNC 4439
MIM 606672
UniProt P07359  
 GP1BA identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GP1BA
Molecular Function
    protein binding GO:0005515 IPI
    thrombin-activated receptor activity GO:0015057 TAS
Biological Process
    cell morphogenesis GO:0000902 IEA
    cell adhesion GO:0007155 IDA
    cell surface receptor signaling pathway GO:0007166 TAS
    blood coagulation GO:0007596 IMP
    blood coagulation, intrinsic pathway GO:0007597 IPI
    blood coagulation, intrinsic pathway GO:0007597 NAS
    positive regulation of platelet activation GO:0010572 IDA
    positive regulation of platelet activation GO:0010572 NAS
    platelet activation GO:0030168 TAS
    regulation of blood coagulation GO:0030193 TAS
    megakaryocyte development GO:0035855 ISO
    megakaryocyte development GO:0035855 NAS
    fibrinolysis GO:0042730 IDA
    release of sequestered calcium ion into cytosol GO:0051209 IDA
    release of sequestered calcium ion into cytosol GO:0051209 NAS
    thrombin-activated receptor signaling pathway GO:0070493 IEA
    positive regulation of leukocyte tethering or rolling GO:1903238 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 HDA
    membrane GO:0016020 IDA
    extracellular matrix GO:0031012 IBA
    extracellular exosome GO:0070062 HDA
    glycoprotein Ib-IX-V complex GO:1990779 IPI
    glycoprotein Ib-IX-V complex GO:1990779 NAS
 Experiment description of studies that identified GP1BA in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GP1BA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F12  
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
2 FLNB 2317
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 APEX1 328
Affinity Capture-RNA Homo sapiens
4 PIK3R1 5295
Reconstituted Complex Homo sapiens
5 DDIT3 1649
Two-hybrid Homo sapiens
6 SELP 6403
Reconstituted Complex Homo sapiens
7 GP5 2814
Affinity Capture-Western Homo sapiens
8 YWHAZ 7534
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 VWF 7450
Co-crystal Structure Homo sapiens
Far Western Homo sapiens
10 FLNA 2316
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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