Gene description for GP1BA
Gene name glycoprotein Ib (platelet), alpha polypeptide
Gene symbol GP1BA
Other names/aliases BDPLT1
BDPLT3
BSS
CD42B
CD42b-alpha
DBPLT3
GP1B
GPIbA
VWDP
Species Homo sapiens
 Database cross references - GP1BA
ExoCarta ExoCarta_2811
Entrez Gene 2811
HGNC 4439
MIM 606672
UniProt P07359  
 GP1BA identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GP1BA
Molecular Function
    thrombin receptor activity GO:0015057 TAS
    protein binding GO:0005515 IPI
Biological Process
    blood coagulation GO:0007596 TAS
    regulation of blood coagulation GO:0030193 TAS
    cell morphogenesis GO:0000902 IEA
    platelet activation GO:0030168 TAS
    thrombin receptor signaling pathway GO:0070493 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    blood coagulation, intrinsic pathway GO:0007597 TAS
    fibrinolysis GO:0042730 IDA
    cell adhesion GO:0007155 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 TAS
    anchored component of external side of plasma membrane GO:0031362 IDA
    cell surface GO:0009986 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GP1BA in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GP1BA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F12  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 FLNB 2317
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 GP1BA 2811
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CTSG 1511
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
5 F11 2160
Reconstituted Complex Homo sapiens
6 SELP 6403
Invivo Homo sapiens
Invitro Homo sapiens
7 GP5 2814
Invivo Homo sapiens
8 YWHAZ 7534
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 OSGEP 55644
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 F2 2147
Invitro Homo sapiens
11 GP9 2815
Invivo Homo sapiens
12 VWF 7450
Invivo Homo sapiens
Invitro Homo sapiens
Co-crystal Structure Homo sapiens
13 FLNA  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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