Gene description for SELP
Gene name
selectin P (granule membrane protein 140kDa, antigen CD62)
Gene symbol
SELP
Other names/aliases
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL
Species
Homo sapiens
Database cross references - SELP
ExoCarta
ExoCarta_6403
Vesiclepedia
VP_6403
Entrez Gene
6403
HGNC
10721
MIM
173610
UniProt
P16109
SELP identified in exosomes derived from the following tissue/cell type
Platelets
10572093
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for SELP
Experiment description of studies that identified SELP in exosomes
1
Experiment ID
31
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
CD63
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Immunoelectron Microscopy
PubMed ID
10572093
Organism
Homo sapiens
Experiment description
Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
Authors
"Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ"
Journal name
BLOOD
Publication year
1999
Sample
Platelets
Sample name
Platelets
Isolation/purification methods
Differential centrifugation Sucrose density gradient
Flotation density
1.14-1.18 g/mL
Molecules identified in the study
Protein
Methods used in the study
Western blotting FACS Immunoelectron Microscopy
2
Experiment ID
231
MISEV standards
✘
Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
3
Experiment ID
232
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
233
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for SELP
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
VCAN
1462
Reconstituted Complex
Homo sapiens
2
GP1BA
2811
Reconstituted Complex
Homo sapiens
3
EZR
7430
Reconstituted Complex
Homo sapiens
4
SNX27
81609
Reconstituted Complex
Homo sapiens
5
SELPLG
6404
Affinity Capture-Western
Homo sapiens
6
AP1M1
8907
Co-crystal Structure
Homo sapiens
7
SERPING1
710
Affinity Capture-Western
Homo sapiens
8
CD24
100133941
Reconstituted Complex
Homo sapiens
9
SNX17
9784
Two-hybrid
Homo sapiens
Co-crystal Structure
Homo sapiens
Protein-peptide
Homo sapiens
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Pathways in which SELP is involved