Gene description for SELPLG
Gene name selectin P ligand
Gene symbol SELPLG
Other names/aliases CD162
CLA
PSGL-1
PSGL1
Species Homo sapiens
 Database cross references - SELPLG
ExoCarta ExoCarta_6404
Entrez Gene 6404
HGNC 10722
MIM 600738
UniProt Q14242  
 SELPLG identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SELPLG
Molecular Function
    protein binding GO:0005515 IPI
    receptor binding GO:0005102 NAS
Biological Process
    leukocyte migration GO:0050900 TAS
    leukocyte adhesive activation GO:0050902 ISS
    blood coagulation GO:0007596 TAS
    cell adhesion GO:0007155 TAS
    cellular response to interleukin-6 GO:0071354 IDA
    leukocyte tethering or rolling GO:0050901 IEA
Subcellular Localization
    membrane GO:0016020 TAS
    uropod GO:0001931 IDA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    integral component of membrane GO:0016021 TAS
 Experiment description of studies that identified SELPLG in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SELPLG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SELPLG 6404
Invitro Homo sapiens
Invitro Homo sapiens
2 SELP 6403
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 MSN 4478
Invitro Homo sapiens
Invivo Homo sapiens
4 SELL 6402
Invivo Homo sapiens
Invitro Homo sapiens
5 TPST1  
Affinity Capture-MS Homo sapiens
6 SELE  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SELPLG is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome





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