Gene description for SELPLG
Gene name selectin P ligand
Gene symbol SELPLG
Other names/aliases CD162
CLA
PSGL-1
PSGL1
Species Homo sapiens
 Database cross references - SELPLG
ExoCarta ExoCarta_6404
Vesiclepedia VP_6404
Entrez Gene 6404
HGNC 10722
MIM 600738
UniProt Q14242  
 SELPLG identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SELPLG
Molecular Function
    virus receptor activity GO:0001618 IEA
    signaling receptor binding GO:0005102 NAS
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 TAS
    symbiont entry into host cell GO:0046718 IEA
    leukocyte migration GO:0050900 IDA
    leukocyte tethering or rolling GO:0050901 IBA
    leukocyte tethering or rolling GO:0050901 IDA
    leukocyte adhesive activation GO:0050902 ISS
    cellular response to interleukin-6 GO:0071354 IDA
Subcellular Localization
    uropod GO:0001931 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    plasma membrane raft GO:0044853 IDA
 Experiment description of studies that identified SELPLG in exosomes
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SELPLG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SELPLG 6404
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 PIK3R1 5295
Affinity Capture-Western Homo sapiens
3 TNIP1 10318
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 MAGEA1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 SELP 6403
Affinity Capture-Western Homo sapiens
6 MSN 4478
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SELPLG is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Hemostasis TAS Reactome





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