Gene description for TNIP1
Gene name TNFAIP3 interacting protein 1
Gene symbol TNIP1
Other names/aliases ABIN-1
NAF1
VAN
nip40-1
Species Homo sapiens
 Database cross references - TNIP1
ExoCarta ExoCarta_10318
Vesiclepedia VP_10318
Entrez Gene 10318
HGNC 16903
MIM 607714
UniProt Q15025  
 TNIP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
 Gene ontology annotations for TNIP1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    mitogen-activated protein kinase binding GO:0051019 IBA
    mitogen-activated protein kinase binding GO:0051019 IDA
Biological Process
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    translation GO:0006412 TAS
    defense response GO:0006952 TAS
    inflammatory response GO:0006954 IEA
    leukocyte cell-cell adhesion GO:0007159 IMP
    glycoprotein biosynthetic process GO:0009101 IDA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IBA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    negative regulation of viral genome replication GO:0045071 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    positive regulation of inflammatory response GO:0050729 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    cellular response to lipopolysaccharide GO:0071222 IBA
    positive regulation of protein deubiquitination GO:1903003 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TNIP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 259
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TNIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABARAPL1 23710
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 MCRS1  
Two-hybrid Homo sapiens
3 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 MAP1LC3C  
Two-hybrid Homo sapiens
5 TNIP1 10318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 AP2B1 163
Proximity Label-MS Homo sapiens
7 ZNHIT1  
Two-hybrid Homo sapiens
8 FAM167A  
Affinity Capture-MS Homo sapiens
9 GRAP2 9402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 PTX3 5806
Affinity Capture-MS Homo sapiens
12 GIT2 9815
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
13 ZC3H14  
Affinity Capture-MS Homo sapiens
14 CRHBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TSG101 7251
Affinity Capture-MS Homo sapiens
16 MDFI  
Affinity Capture-MS Homo sapiens
17 BYSL 705
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 UBC 7316
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
19 FAM168A  
Two-hybrid Homo sapiens
20 CORO6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MAPK10 5602
Two-hybrid Homo sapiens
22 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PIK3CD 5293
Affinity Capture-Western Homo sapiens
24 NFKB1 4790
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
25 DPPA4  
Two-hybrid Homo sapiens
26 WTAP 9589
Two-hybrid Homo sapiens
27 SELPLG 6404
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
28 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 NME7 29922
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 RNF8  
Two-hybrid Homo sapiens
31 CCDC112  
Two-hybrid Homo sapiens
32 DMD 1756
Affinity Capture-MS Homo sapiens
33 EFEMP1 2202
Two-hybrid Homo sapiens
34 IKBKE 9641
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 TCEANC2  
Two-hybrid Homo sapiens
36 NIFK 84365
Two-hybrid Homo sapiens
37 KRTAP19-5  
Two-hybrid Homo sapiens
38 ABHD17A 81926
Two-hybrid Homo sapiens
39 MOB3C  
Two-hybrid Homo sapiens
40 RNF11 26994
Two-hybrid Homo sapiens
41 TNF  
Affinity Capture-MS Homo sapiens
42 MAPK1 5594
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
43 KRT8 3856
Proximity Label-MS Homo sapiens
44 NRSN1  
Affinity Capture-MS Homo sapiens
45 IKBIP 121457
Affinity Capture-MS Homo sapiens
46 IRAK1  
Affinity Capture-Western Homo sapiens
47 CDKN1A  
Two-hybrid Homo sapiens
48 PNKP 11284
Two-hybrid Homo sapiens
49 TCEA2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 SAMD4A 23034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 OPTN 10133
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PSMD14 10213
Affinity Capture-MS Homo sapiens
53 KRTAP8-1  
Two-hybrid Homo sapiens
54 DAZAP2  
Two-hybrid Homo sapiens
55 ABI2 10152
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MCM10 55388
Two-hybrid Homo sapiens
57 KRTAP6-2  
Two-hybrid Homo sapiens
58 GTF2H1 2965
Two-hybrid Homo sapiens
59 BTF3 689
Affinity Capture-MS Homo sapiens
60 HAO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CYSRT1 375791
Two-hybrid Homo sapiens
62 PIGT 51604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ADH6 130
Two-hybrid Homo sapiens
65 SPATA2  
Two-hybrid Homo sapiens
66 SUMO2 6613
Two-hybrid Homo sapiens
67 PIK3R1 5295
Affinity Capture-Western Homo sapiens
68 TNIP3  
Two-hybrid Homo sapiens
69 MAGEH1  
Two-hybrid Homo sapiens
70 MAGEB18  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
71 MOB1B 92597
Two-hybrid Homo sapiens
72 CEP135  
Proximity Label-MS Homo sapiens
73 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
74 XPO1 7514
Affinity Capture-MS Homo sapiens
75 GLMN 11146
Affinity Capture-MS Homo sapiens
76 Ikbkg  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
77 NFKBIA  
Co-fractionation Homo sapiens
78 AP1M1 8907
Two-hybrid Homo sapiens
79 HDDC3  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
80 SYT6  
Two-hybrid Homo sapiens
81 CARD11  
Affinity Capture-Western Homo sapiens
82 MAP3K1 4214
Biochemical Activity Homo sapiens
83 RBFOX1 54715
Two-hybrid Homo sapiens
84 FUS 2521
Two-hybrid Homo sapiens
85 TTF2 8458
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
86 MORF4L1  
Two-hybrid Homo sapiens
87 DUSP16  
Affinity Capture-MS Homo sapiens
88 TRAF3 7187
Affinity Capture-Western Homo sapiens
89 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 RABAC1 10567
Two-hybrid Homo sapiens
91 ZBTB25  
Two-hybrid Homo sapiens
92 NDC80 10403
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
93 PTPN23 25930
Proximity Label-MS Homo sapiens
94 CCNG1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 KRTAP6-1  
Two-hybrid Homo sapiens
96 TCEANC  
Two-hybrid Homo sapiens
97 STIL  
Proximity Label-MS Homo sapiens
98 KRTAP6-3  
Two-hybrid Homo sapiens
99 RARG  
Two-hybrid Homo sapiens
100 TXLNA 200081
Two-hybrid Homo sapiens
101 RALBP1 10928
Two-hybrid Homo sapiens
102 C8orf33 65265
Two-hybrid Homo sapiens
103 RARA 5914
Two-hybrid Homo sapiens
104 CDIP1 29965
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 KIAA1598 57698
Two-hybrid Homo sapiens
106 CFAP53  
Two-hybrid Homo sapiens
107 VPS28 51160
Affinity Capture-MS Homo sapiens
108 KRTAP19-3  
Two-hybrid Homo sapiens
109 ZMAT2  
Two-hybrid Homo sapiens
110 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
111 BFSP1  
Affinity Capture-MS Homo sapiens
112 EHHADH 1962
Two-hybrid Homo sapiens
113 CDC37 11140
Two-hybrid Homo sapiens
114 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
115 MAP1LC3B 81631
Two-hybrid Homo sapiens
116 GABARAPL2 11345
Two-hybrid Homo sapiens
117 LITAF 9516
Two-hybrid Homo sapiens
118 LENG8  
Two-hybrid Homo sapiens
119 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
120 MORF4L2  
Two-hybrid Homo sapiens
121 BCL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
122 TYRO3 7301
Two-hybrid Homo sapiens
123 GTF2B 2959
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 BRK1 55845
Affinity Capture-MS Homo sapiens
125 KRTAP19-7  
Two-hybrid Homo sapiens
126 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 MAP1LC3A 84557
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
128 SNIP1  
Two-hybrid Homo sapiens
129 CCDC121  
Two-hybrid Homo sapiens
130 NAB2 4665
Affinity Capture-MS Homo sapiens
131 FAM161A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
132 LRRC61 65999
Proximity Label-MS Homo sapiens
133 MYD88 4615
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
134 TNNC2  
Affinity Capture-MS Homo sapiens
135 VPS33B 26276
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 IKBKB 3551
Co-fractionation Homo sapiens
137 LURAP1  
Affinity Capture-MS Homo sapiens
138 TRAF1 7185
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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