Gene description for RABAC1
Gene name Rab acceptor 1 (prenylated)
Gene symbol RABAC1
Other names/aliases PRA1
PRAF1
YIP3
Species Homo sapiens
 Database cross references - RABAC1
ExoCarta ExoCarta_10567
Vesiclepedia VP_10567
Entrez Gene 10567
HGNC 9794
MIM 604925
UniProt Q9UI14  
 RABAC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RABAC1
Molecular Function
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 IEA
    proline-rich region binding GO:0070064 IEA
    identical protein binding GO:0042802 IPI
Subcellular Localization
    membrane GO:0016020 IDA
    synaptic vesicle GO:0008021 IEA
    plasma membrane GO:0005886 IEA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified RABAC1 in exosomes
1
Experiment ID 489
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
ISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
ISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RABAC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB22A 57403
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 RAB33A 9363
Two-hybrid Homo sapiens
3 TUBB2A 7280
Two-hybrid Homo sapiens
4 FLJ10204  
Two-hybrid Homo sapiens
5 FAM160A2 84067
Two-hybrid Homo sapiens
6 RAB6A 5870
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
7 CABC1  
Two-hybrid Homo sapiens
8 SNX15  
Two-hybrid Homo sapiens
9 RAB1A 5861
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 RAB5A 5868
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
11 FLJ22494  
Two-hybrid Homo sapiens
12 SMCR7  
Two-hybrid Homo sapiens
13 RAB17 64284
Two-hybrid Homo sapiens
14 SPG21 51324
Two-hybrid Homo sapiens
15 PLEKHF2 79666
Two-hybrid Homo sapiens
16 VAMP2 6844
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
17 VTA1 51534
Two-hybrid Homo sapiens
18 RAB4A 5867
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
19 RRAS2 22800
Affinity Capture-MS Homo sapiens
20 DUSP12 11266
Two-hybrid Homo sapiens
21 RABAC1 10567
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 FXR2 9513
Two-hybrid Homo sapiens
23 RIMS2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
24 LNX  
Two-hybrid Homo sapiens
25 RAB7A 7879
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
26 RAP1A 5906
Affinity Capture-MS Homo sapiens
27 RAB5C 5878
Invitro Homo sapiens
Two-hybrid Homo sapiens
28 GDI1  
Affinity Capture-MS Homo sapiens
29 RAB3A 5864
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
30 RAB4B 53916
Two-hybrid Homo sapiens
31 VIM 7431
Two-hybrid Homo sapiens
32 RHOA 387
Affinity Capture-MS Homo sapiens
33 NIF3L1 60491
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RABAC1 is involved
No pathways found





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