Gene description for RABAC1
Gene name Rab acceptor 1 (prenylated)
Gene symbol RABAC1
Other names/aliases PRA1
PRAF1
YIP3
Species Homo sapiens
 Database cross references - RABAC1
ExoCarta ExoCarta_10567
Vesiclepedia VP_10567
Entrez Gene 10567
HGNC 9794
MIM 604925
UniProt Q9UI14  
 RABAC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RABAC1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    GTPase binding GO:0051020 IEA
    proline-rich region binding GO:0070064 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IBA
    plasma membrane GO:0005886 IEA
    synaptic vesicle GO:0008021 IEA
    membrane GO:0016020 HDA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified RABAC1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RABAC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F11R 50848
Two-hybrid Homo sapiens
2 TNIP1 10318
Two-hybrid Homo sapiens
3 SNX15  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 RAB1A 5861
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
5 MCF2L  
Two-hybrid Homo sapiens
6 ADCK3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
8 RIN3  
Two-hybrid Homo sapiens
9 EMP1  
Two-hybrid Homo sapiens
10 PLEKHF2 79666
Two-hybrid Homo sapiens
11 VAMP2 6844
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 RET 5979
Affinity Capture-MS Homo sapiens
13 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
14 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DUSP12 11266
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 RPS20 6224
Two-hybrid Homo sapiens
17 RNF5  
Two-hybrid Homo sapiens
18 SLAMF6 114836
Two-hybrid Homo sapiens
19 RER1 11079
Affinity Capture-MS Homo sapiens
20 RAB5B 5869
Two-hybrid Homo sapiens
21 NAT8B  
Affinity Capture-MS Homo sapiens
22 SSR3 6747
Two-hybrid Homo sapiens
23 TMEM136  
Affinity Capture-MS Homo sapiens
24 MAD2L1 4085
Two-hybrid Homo sapiens
25 NIF3L1 60491
Two-hybrid Homo sapiens
26 RAB1B 81876
Affinity Capture-MS Homo sapiens
27 LTBR 4055
Two-hybrid Homo sapiens
28 STOML2 30968
Two-hybrid Homo sapiens
29 SPG21 51324
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 TMEM14B  
Two-hybrid Homo sapiens
31 HRG 3273
Two-hybrid Homo sapiens
32 RGS2  
Two-hybrid Homo sapiens
33 TMEM115 11070
Two-hybrid Homo sapiens
34 IFITM3 10410
Affinity Capture-MS Homo sapiens
35 NUDT18  
Two-hybrid Homo sapiens
36 UBE2I 7329
Two-hybrid Homo sapiens
37 SH3GL3  
Two-hybrid Homo sapiens
38 KDSR 2531
Affinity Capture-MS Homo sapiens
39 RAB43 339122
Affinity Capture-MS Homo sapiens
40 WDYHV1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 SFT2D3  
Affinity Capture-MS Homo sapiens
42 SNX11 29916
Two-hybrid Homo sapiens
43 WIPI2 26100
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 PLK1 5347
Two-hybrid Homo sapiens
45 TRIM32 22954
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 CREB3  
Two-hybrid Homo sapiens
47 EPHB6  
Affinity Capture-MS Homo sapiens
48 Katna1  
Affinity Capture-MS Mus musculus
49 TXN2 25828
Two-hybrid Homo sapiens
50 REEP5 7905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
51 SNX1 6642
Two-hybrid Homo sapiens
52 SFT2D1 113402
Affinity Capture-MS Homo sapiens
53 CYP2A6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 C4orf32  
Affinity Capture-MS Homo sapiens
55 TMED9 54732
Affinity Capture-MS Homo sapiens
56 RAB5A 5868
Two-hybrid Homo sapiens
57 NDFIP2 54602
Affinity Capture-MS Homo sapiens
58 KCNK18  
Affinity Capture-MS Homo sapiens
59 CRB3 92359
Two-hybrid Homo sapiens
60 GOLT1B 51026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TMEM128  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 STIM1 6786
Two-hybrid Homo sapiens
63 TMEM42  
Two-hybrid Homo sapiens
64 HSD17B13  
Two-hybrid Homo sapiens
65 YIPF5 81555
Affinity Capture-MS Homo sapiens
66 NAT14 57106
Two-hybrid Homo sapiens
67 RIC8A 60626
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 GPR152  
Two-hybrid Homo sapiens
69 NDRG4 65009
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
70 FAM134C 162427
Two-hybrid Homo sapiens
71 RABAC1 10567
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 RPA3 6119
Proximity Label-MS Homo sapiens
73 FXR2 9513
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 SNX8 29886
Two-hybrid Homo sapiens
75 SNX10 29887
Two-hybrid Homo sapiens
76 CMTM5  
Affinity Capture-MS Homo sapiens
77 RAB9A 9367
Affinity Capture-MS Homo sapiens
78 ZFYVE21  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 C6orf47  
Two-hybrid Homo sapiens
80 RAB3A 5864
Two-hybrid Homo sapiens
81 LEMD3  
Two-hybrid Homo sapiens
82 PBX3  
Two-hybrid Homo sapiens
83 TMX2 51075
Two-hybrid Homo sapiens
84 RAB33A 9363
Two-hybrid Homo sapiens
85 TUBB2A 7280
Two-hybrid Homo sapiens
86 SNCA 6622
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
87 FAM160A2 84067
Two-hybrid Homo sapiens
88 SGK1  
Two-hybrid Homo sapiens
89 TMEM208  
Affinity Capture-MS Homo sapiens
90 SIDT2 51092
Affinity Capture-MS Homo sapiens
91 RTN3 10313
Affinity Capture-MS Homo sapiens
92 SYT16  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 CMTM3 123920
Two-hybrid Homo sapiens
94 NR3C2  
Two-hybrid Homo sapiens
95 CACNG6  
Affinity Capture-MS Homo sapiens
96 VTA1 51534
Two-hybrid Homo sapiens
97 REEP2  
Two-hybrid Homo sapiens
98 DDX58 23586
Affinity Capture-RNA Homo sapiens
99 MIF 4282
Affinity Capture-MS Homo sapiens
100 RHEB 6009
Two-hybrid Homo sapiens
101 RAB2A 5862
Affinity Capture-MS Homo sapiens
102 MIEF2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
103 RAB7A 7879
Affinity Capture-MS Homo sapiens
104 EI24  
Two-hybrid Homo sapiens
105 RAB5C 5878
Proximity Label-MS Homo sapiens
106 VIM 7431
Two-hybrid Homo sapiens
107 RAB2B 84932
Affinity Capture-MS Homo sapiens
108 LNX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
109 SNX17 9784
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RABAC1 is involved
No pathways found





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