Gene description for SNX8
Gene name sorting nexin 8
Gene symbol SNX8
Other names/aliases Mvp1
Species Homo sapiens
 Database cross references - SNX8
ExoCarta ExoCarta_29886
Vesiclepedia VP_29886
Entrez Gene 29886
HGNC 14972
MIM 614905
UniProt Q9Y5X2  
 SNX8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SNX8
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IMP
    identical protein binding GO:0042802 IPI
Biological Process
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 IMP
    early endosome to Golgi transport GO:0034498 IBA
    early endosome to Golgi transport GO:0034498 IMP
Subcellular Localization
    cytosol GO:0005829 IEA
    retromer complex GO:0030904 IDA
    early endosome membrane GO:0031901 IBA
    early endosome membrane GO:0031901 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified SNX8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SNX8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAVS 57506
Affinity Capture-Western Homo sapiens
2 POR 5447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 WLS 79971
Affinity Capture-MS Homo sapiens
4 C14orf119  
Two-hybrid Homo sapiens
5 TOLLIP 54472
Co-fractionation Homo sapiens
6 MEX3A  
Affinity Capture-RNA Homo sapiens
7 ATP6V1D 51382
Co-fractionation Homo sapiens
8 AKT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KARS 3735
Co-fractionation Homo sapiens
10 RUFY1 80230
Affinity Capture-MS Homo sapiens
11 PARK2  
Affinity Capture-MS Homo sapiens
12 LACC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SHMT2 6472
Affinity Capture-RNA Homo sapiens
14 NFIL3 4783
Affinity Capture-MS Homo sapiens
15 TMEM47 83604
Affinity Capture-MS Homo sapiens
16 MSH3 4437
Co-fractionation Homo sapiens
17 THUMPD2  
Co-fractionation Homo sapiens
18 NXF1 10482
Affinity Capture-RNA Homo sapiens
19 CFP  
Affinity Capture-MS Homo sapiens
20 MOV10 4343
Affinity Capture-RNA Homo sapiens
21 RABAC1 10567
Two-hybrid Homo sapiens
22 ARL6IP1 23204
Two-hybrid Homo sapiens
23 WNT5A 7474
Affinity Capture-MS Homo sapiens
24 RXRG  
Affinity Capture-MS Homo sapiens
25 FBXW7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZWILCH 55055
Co-fractionation Homo sapiens
27 POLR3GL  
Affinity Capture-MS Homo sapiens
28 REEP6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SNX8 is involved
No pathways found





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