Gene description for NFIL3
Gene name nuclear factor, interleukin 3 regulated
Gene symbol NFIL3
Other names/aliases E4BP4
IL3BP1
NF-IL3A
NFIL3A
Species Homo sapiens
 Database cross references - NFIL3
ExoCarta ExoCarta_4783
Entrez Gene 4783
HGNC 7787
MIM 605327
UniProt Q16649  
 NFIL3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for NFIL3
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    DNA binding GO:0003677 TAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
    transcription corepressor activity GO:0003714 TAS
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
Biological Process
    positive regulation of gene expression GO:0010628 IEA
    circadian rhythm GO:0007623 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    immune response GO:0006955 IEA
    cellular response to interleukin-4 GO:0071353 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified NFIL3 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for NFIL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CREB3L1  
Affinity Capture-MS Homo sapiens
2 CREB3  
Affinity Capture-MS Homo sapiens
3 DR1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 DDIT3 1649
Affinity Capture-MS Homo sapiens
5 BATF  
Affinity Capture-MS Homo sapiens
6 CREM  
Affinity Capture-MS Homo sapiens
7 NFIL3 4783
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CEBPG  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NFIL3 is involved
No pathways found





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