Gene description for RINT1
Gene name RAD50 interactor 1
Gene symbol RINT1
Other names/aliases RINT-1
Species Homo sapiens
 Database cross references - RINT1
ExoCarta ExoCarta_60561
Vesiclepedia VP_60561
Entrez Gene 60561
HGNC 21876
MIM 610089
UniProt Q6NUQ1  
 RINT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RINT1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IEA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 NAS
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IMP
    protein transport GO:0015031 IEA
    regulation of ER to Golgi vesicle-mediated transport GO:0060628 IBA
    regulation of ER to Golgi vesicle-mediated transport GO:0060628 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 TAS
    Dsl1/NZR complex GO:0070939 IBA
    Dsl1/NZR complex GO:0070939 IDA
    Dsl1/NZR complex GO:0070939 IPI
 Experiment description of studies that identified RINT1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RINT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 HDAC4  
Two-hybrid Homo sapiens
4 CCDC88B 283234
Two-hybrid Homo sapiens
5 P2RY10  
Affinity Capture-MS Homo sapiens
6 BLOC1S6  
Two-hybrid Homo sapiens
7 KRT1 3848
Two-hybrid Homo sapiens
8 LSP1P3  
Two-hybrid Homo sapiens
9 METTL7A 25840
Proximity Label-MS Homo sapiens
10 NAPA 8775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SCNM1  
Two-hybrid Homo sapiens
12 TSHZ2  
Two-hybrid Homo sapiens
13 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 BNIP1 662
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SMARCE1 6605
Two-hybrid Homo sapiens
16 TMEM9B 56674
Affinity Capture-MS Homo sapiens
17 RBM41  
Two-hybrid Homo sapiens
18 BFSP2  
Two-hybrid Homo sapiens
19 DNAJC25 548645
Proximity Label-MS Homo sapiens
20 ZNF697  
Two-hybrid Homo sapiens
21 PTPN1 5770
Proximity Label-MS Homo sapiens
22 NFIL3 4783
Two-hybrid Homo sapiens
23 STX4 6810
Proximity Label-MS Homo sapiens
24 C5AR1  
Affinity Capture-MS Homo sapiens
25 RTP5  
Two-hybrid Homo sapiens
26 CWF19L2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 LMO2  
Two-hybrid Homo sapiens
28 ZNF648  
Two-hybrid Homo sapiens
29 RDX 5962
Affinity Capture-MS Homo sapiens
30 STRN 6801
Two-hybrid Homo sapiens
31 CEP57L1  
Two-hybrid Homo sapiens
32 KIR2DL4  
Affinity Capture-MS Homo sapiens
33 ESRRG  
Two-hybrid Homo sapiens
34 INPP5J  
Two-hybrid Homo sapiens
35 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NBAS 51594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SSR1 6745
Proximity Label-MS Homo sapiens
38 STX18 53407
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PIGH  
Affinity Capture-MS Homo sapiens
40 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 STX6 10228
Proximity Label-MS Homo sapiens
42 ITFG3 83986
Affinity Capture-MS Homo sapiens
43 F2RL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BET1 10282
Affinity Capture-MS Homo sapiens
45 TACO1  
Two-hybrid Homo sapiens
46 ARNT2  
Two-hybrid Homo sapiens
47 PTH1R  
Affinity Capture-MS Homo sapiens
48 GFI1B  
Two-hybrid Homo sapiens
49 FAS 355
Proximity Label-MS Homo sapiens
50 NUP155 9631
Proximity Label-MS Homo sapiens
51 KIAA1715 80856
Proximity Label-MS Homo sapiens
52 RB1 5925
Reconstituted Complex Homo sapiens
53 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RAB5A 5868
Proximity Label-MS Homo sapiens
55 KIAA1217 56243
Two-hybrid Homo sapiens
56 SCFD1 23256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 C19orf44  
Two-hybrid Homo sapiens
58 FAM161B  
Two-hybrid Homo sapiens
59 EMD 2010
Proximity Label-MS Homo sapiens
60 MYOZ3  
Two-hybrid Homo sapiens
61 ZBTB16  
Two-hybrid Homo sapiens
62 SFR1 119392
Two-hybrid Homo sapiens
63 FAM110A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 MGC50722  
Two-hybrid Homo sapiens
65 CDR2L  
Two-hybrid Homo sapiens
66 FAM107A  
Two-hybrid Homo sapiens
67 RSRC2  
Two-hybrid Homo sapiens
68 CCDC57 284001
Two-hybrid Homo sapiens
69 DPF2  
Two-hybrid Homo sapiens
70 ZNF655  
Two-hybrid Homo sapiens
71 SPAG5 10615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CCDC101  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 PRPF18  
Two-hybrid Homo sapiens
74 GNAI2 2771
Affinity Capture-MS Homo sapiens
75 DGCR2 9993
Affinity Capture-MS Homo sapiens
76 FAM124B  
Two-hybrid Homo sapiens
77 UTP14C  
Two-hybrid Homo sapiens
78 ELOVL5 60481
Proximity Label-MS Homo sapiens
79 SEC61B 10952
Proximity Label-MS Homo sapiens
80 RNF39  
Two-hybrid Homo sapiens
81 GOLT1B 51026
Affinity Capture-MS Homo sapiens
82 MLNR  
Affinity Capture-MS Homo sapiens
83 SUOX  
Two-hybrid Homo sapiens
84 RBL1  
Reconstituted Complex Homo sapiens
85 REEP5 7905
Proximity Label-MS Homo sapiens
86 SEC63 11231
Proximity Label-MS Homo sapiens
87 P2RY2 5029
Affinity Capture-MS Homo sapiens
88 NTRK1 4914
Affinity Capture-MS Homo sapiens
89 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 HMHA1 23526
Two-hybrid Homo sapiens
91 EFNA4  
Affinity Capture-MS Homo sapiens
92 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ZSCAN5B  
Two-hybrid Homo sapiens
95 LRRC59 55379
Proximity Label-MS Homo sapiens
96 PANX1 24145
Proximity Label-MS Homo sapiens
97 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 CCDC120  
Two-hybrid Homo sapiens
99 NPTN 27020
Affinity Capture-MS Homo sapiens
100 CD274 29126
Affinity Capture-MS Homo sapiens
101 BCAP31 10134
Proximity Label-MS Homo sapiens
102 HSD3B7 80270
Proximity Label-MS Homo sapiens
103 STIM1 6786
Proximity Label-MS Homo sapiens
104 YLPM1 56252
Co-fractionation Homo sapiens
105 ZNF835  
Two-hybrid Homo sapiens
106 VAMP3 9341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 FAM90A1  
Two-hybrid Homo sapiens
108 FOXL1  
Affinity Capture-MS Homo sapiens
109 METTL21B  
Affinity Capture-MS Homo sapiens
110 OPRL1 4987
Affinity Capture-MS Homo sapiens
111 OCIAD1 54940
Affinity Capture-MS Homo sapiens
112 ZW10 9183
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 LYSMD1  
Two-hybrid Homo sapiens
115 PTPRJ 5795
Proximity Label-MS Homo sapiens
116 NIN 51199
Proximity Label-MS Homo sapiens
117 ATP2A1 487
Proximity Label-MS Homo sapiens
118 FCHSD2  
Two-hybrid Homo sapiens
119 RBL2 5934
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
120 RIBC1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 JMY  
Two-hybrid Homo sapiens
122 TSEN54  
Two-hybrid Homo sapiens
123 PTPRN  
Affinity Capture-MS Homo sapiens
124 DNAJC1 64215
Proximity Label-MS Homo sapiens
125 DCX  
Two-hybrid Homo sapiens
126 USHBP1  
Two-hybrid Homo sapiens
127 CTNNA1 1495
Proximity Label-MS Homo sapiens
128 ZC2HC1C  
Two-hybrid Homo sapiens
129 FAM103A1  
Two-hybrid Homo sapiens
130 AVPR2  
Affinity Capture-MS Homo sapiens
131 TXLNA 200081
Two-hybrid Homo sapiens
132 GPR17 2840
Affinity Capture-MS Homo sapiens
133 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
134 USE1 55850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 TMEM9 252839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 TSHZ3  
Two-hybrid Homo sapiens
137 SCFD2 152579
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 TVP23C  
Affinity Capture-MS Homo sapiens
139 EXOC8 149371
Two-hybrid Homo sapiens
140 PGRMC1 10857
Affinity Capture-MS Homo sapiens
141 VPS37C 55048
Two-hybrid Homo sapiens
142 CCHCR1  
Two-hybrid Homo sapiens
143 CCDC146  
Two-hybrid Homo sapiens
144 Zw10  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
145 VAMP4 8674
Affinity Capture-MS Homo sapiens
146 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 C1orf35  
Two-hybrid Homo sapiens
148 DCTN2 10540
Two-hybrid Homo sapiens
149 CSPP1  
Two-hybrid Homo sapiens
150 EPC1  
Two-hybrid Homo sapiens
151 C19orf25  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 RAD50 10111
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 GAS8  
Two-hybrid Homo sapiens
154 ERGIC2 51290
Proximity Label-MS Homo sapiens
155 FAM81B  
Two-hybrid Homo sapiens
156 SEC62 7095
Proximity Label-MS Homo sapiens
157 CCDC121  
Two-hybrid Homo sapiens
158 STX3 6809
Affinity Capture-MS Homo sapiens
159 NAB2 4665
Two-hybrid Homo sapiens
160 FAM161A  
Two-hybrid Homo sapiens
161 RAB7A 7879
Proximity Label-MS Homo sapiens
162 C1orf109  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
163 ANKRD11 29123
Two-hybrid Homo sapiens
164 TRIM69 140691
Two-hybrid Homo sapiens
165 VAMP5 10791
Affinity Capture-MS Homo sapiens
166 PIK3R2 5296
Two-hybrid Homo sapiens
167 SNW1 22938
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
168 C3orf18  
Affinity Capture-MS Homo sapiens
169 SH2D4A 63898
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
170 CCR6  
Affinity Capture-MS Homo sapiens
171 CKAP4 10970
Proximity Label-MS Homo sapiens
172 S1PR4  
Affinity Capture-MS Homo sapiens
173 VAV3 10451
Two-hybrid Homo sapiens
174 RPA3 6119
Proximity Label-MS Homo sapiens
175 C17orf59 54785
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 DERL1 79139
Proximity Label-MS Homo sapiens
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