Gene description for VAMP4
Gene name vesicle-associated membrane protein 4
Gene symbol VAMP4
Other names/aliases VAMP-4
VAMP24
Species Homo sapiens
 Database cross references - VAMP4
ExoCarta ExoCarta_8674
Vesiclepedia VP_8674
Entrez Gene 8674
HGNC 12645
MIM 606909
UniProt O75379  
 VAMP4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VAMP4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    synaptic vesicle to endosome fusion GO:0016189 IEA
    endocytic recycling GO:0032456 IMP
    SNARE complex assembly GO:0035493 IBA
    SNARE complex assembly GO:0035493 IDA
    Golgi ribbon formation GO:0090161 IEA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IEA
    vesicle-mediated transport in synapse GO:0099003 IEA
    regulation of synaptic vesicle endocytosis GO:1900242 IEA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    lysosome GO:0005764 TAS
    endosome GO:0005768 TAS
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    transport vesicle GO:0030133 TAS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    SNARE complex GO:0031201 IBA
    trans-Golgi network membrane GO:0032588 TAS
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified VAMP4 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VAMP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 Anapc13  
Affinity Capture-MS Mus musculus
4 SLC10A6  
Two-hybrid Homo sapiens
5 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SNAP23 8773
Affinity Capture-MS Homo sapiens
8 METTL7A 25840
Proximity Label-MS Homo sapiens
9 LAMP3  
Proximity Label-MS Homo sapiens
10 ATG9A 79065
Proximity Label-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
12 PSCA 8000
Two-hybrid Homo sapiens
13 TMEM205 374882
Two-hybrid Homo sapiens
14 NBAS 51594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 GOSR2 9570
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CLEC12A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 STX4 6810
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TRIM54  
Two-hybrid Homo sapiens
21 ITFG1 81533
Affinity Capture-MS Homo sapiens
22 B3GAT1  
Proximity Label-MS Homo sapiens
23 STX1A 6804
Two-hybrid Homo sapiens
24 WASH3P  
Affinity Capture-MS Homo sapiens
25 RINT1 60561
Affinity Capture-MS Homo sapiens
26 PACS1 55690
Affinity Capture-Western Homo sapiens
27 STX8 9482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GALM 130589
Affinity Capture-MS Homo sapiens
30 STX18 53407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SYT2  
Two-hybrid Homo sapiens
32 SLITRK3  
Affinity Capture-MS Homo sapiens
33 STX6 10228
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ITFG3 83986
Affinity Capture-MS Homo sapiens
35 SEC11C 90701
Two-hybrid Homo sapiens
36 VPS53 55275
Affinity Capture-Western Homo sapiens
37 RAB35 11021
Proximity Label-MS Homo sapiens
38 GPX8 493869
Two-hybrid Homo sapiens
39 CSNK2B 1460
Affinity Capture-MS Homo sapiens
40 EBAG9 9166
Proximity Label-MS Homo sapiens
41 TMEM59 9528
Affinity Capture-MS Homo sapiens
42 SSMEM1  
Two-hybrid Homo sapiens
43 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NTMT1 28989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 LAMTOR1 55004
Proximity Label-MS Homo sapiens
46 VTI1A 143187
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 OXSM  
Affinity Capture-MS Homo sapiens
48 SCFD1 23256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 NAPA 8775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BNIP1 662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 VPS45 11311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 REEP4  
Two-hybrid Homo sapiens
53 ZNF526  
Affinity Capture-MS Homo sapiens
54 STOM 2040
Two-hybrid Homo sapiens
55 Taf15  
Affinity Capture-MS Mus musculus
56 MCAM 4162
Proximity Label-MS Homo sapiens
57 RAB4A 5867
Proximity Label-MS Homo sapiens
58 SNAP47 116841
Affinity Capture-MS Homo sapiens
59 ANKS6 203286
Two-hybrid Homo sapiens
60 EVI2B 2124
Two-hybrid Homo sapiens
61 SERPINB8 5271
Affinity Capture-MS Homo sapiens
62 PLK1 5347
Affinity Capture-MS Homo sapiens
63 TNFRSF10C  
Affinity Capture-MS Homo sapiens
64 NAPG 8774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 STX5 6811
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ARL13B 200894
Two-hybrid Homo sapiens
67 ELOVL5 60481
Proximity Label-MS Homo sapiens
68 MFF 56947
Two-hybrid Homo sapiens
69 SNAP29 9342
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CLINT1 9685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RAB5A 5868
Proximity Label-MS Homo sapiens
72 MTIF3  
Two-hybrid Homo sapiens
73 TM4SF19  
Two-hybrid Homo sapiens
74 RAB11A 8766
Proximity Label-MS Homo sapiens
75 LAMP1 3916
Proximity Label-MS Homo sapiens
76 ERGIC3 51614
Two-hybrid Homo sapiens
77 AP1M1 8907
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
78 CSNK2A1 1457
Biochemical Activity Homo sapiens
79 ARF6 382
Proximity Label-MS Homo sapiens
80 COX6B1 1340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 KIAA1467 57613
Affinity Capture-MS Homo sapiens
82 LEUTX  
Two-hybrid Homo sapiens
83 GPR152  
Two-hybrid Homo sapiens
84 FAM209A 200232
Two-hybrid Homo sapiens
85 PTGES 9536
Two-hybrid Homo sapiens
86 CCDC155  
Two-hybrid Homo sapiens
87 FAM134C 162427
Two-hybrid Homo sapiens
88 LSMEM2  
Affinity Capture-MS Homo sapiens
89 CPLX4  
Two-hybrid Homo sapiens
90 RAB9A 9367
Proximity Label-MS Homo sapiens
91 GOLGA1  
Proximity Label-MS Homo sapiens
92 STX10 8677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TMX2 51075
Two-hybrid Homo sapiens
94 NSF 4905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 UBE3B 89910
Affinity Capture-MS Homo sapiens
96 TMEM51 55092
Two-hybrid Homo sapiens
97 ANKFY1 51479
Proximity Label-MS Homo sapiens
98 USE1 55850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 STX16 8675
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
100 SCFD2 152579
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 VPS52 6293
Affinity Capture-Western Homo sapiens
102 GOSR1 9527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 HECTD4 283450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 C1orf123 54987
Affinity Capture-MS Homo sapiens
105 LDLRAD1  
Two-hybrid Homo sapiens
106 EBP  
Two-hybrid Homo sapiens
107 HS6ST2 90161
Affinity Capture-MS Homo sapiens
108 C19orf25  
Affinity Capture-MS Homo sapiens
109 NAPB 63908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ZW10 9183
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 RABL3 285282
Affinity Capture-MS Homo sapiens
112 ERGIC2 51290
Proximity Label-MS Homo sapiens
113 BCL2L13 23786
Two-hybrid Homo sapiens
114 RAB2A 5862
Proximity Label-MS Homo sapiens
115 STX3 6809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 CLTA 1211
Affinity Capture-MS Homo sapiens
117 CISD2 493856
Two-hybrid Homo sapiens
118 KRAS 3845
Proximity Label-MS Homo sapiens
119 RAB5C 5878
Proximity Label-MS Homo sapiens
120 CAV1 857
Proximity Label-MS Homo sapiens
121 ELOVL4  
Two-hybrid Homo sapiens
122 MGST3 4259
Two-hybrid Homo sapiens
123 FAM210B  
Two-hybrid Homo sapiens
View the network image/svg+xml



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