Gene description for SEC11C
Gene name SEC11 homolog C (S. cerevisiae)
Gene symbol SEC11C
Other names/aliases SEC11L3
SPC21
SPCS4C
Species Homo sapiens
 Database cross references - SEC11C
ExoCarta ExoCarta_90701
Vesiclepedia VP_90701
Entrez Gene 90701
HGNC 23400
UniProt Q9BY50  
 SEC11C identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SEC11C
Molecular Function
    serine-type endopeptidase activity GO:0004252 IDA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IBA
Biological Process
    signal peptide processing GO:0006465 IBA
    signal peptide processing GO:0006465 IDA
Subcellular Localization
    signal peptidase complex GO:0005787 IBA
    signal peptidase complex GO:0005787 IDA
    signal peptidase complex GO:0005787 IPI
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified SEC11C in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SEC11C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FBXL14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ADAM30 11085
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C2 717
Two-hybrid Homo sapiens
4 TMEM128  
Two-hybrid Homo sapiens
5 SPCS3 60559
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TSNARE1  
Two-hybrid Homo sapiens
7 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 LMAN1L  
Affinity Capture-MS Homo sapiens
9 CHRNA4  
Affinity Capture-MS Homo sapiens
10 TTYH1  
Affinity Capture-MS Homo sapiens
11 STX12 23673
Two-hybrid Homo sapiens
12 VAPA 9218
Two-hybrid Homo sapiens
13 TMEM254  
Two-hybrid Homo sapiens
14 RTP2  
Two-hybrid Homo sapiens
15 GGT7 2686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GABRA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SELM 140606
Two-hybrid Homo sapiens
18 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GLP1R  
PCA Homo sapiens
20 ALPL 249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VAMP4 8674
Two-hybrid Homo sapiens
22 GHDC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BTN2A2  
Two-hybrid Homo sapiens
24 WNT6  
Affinity Capture-MS Homo sapiens
25 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 FUNDC2 65991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CADM3  
Two-hybrid Homo sapiens
28 APOM 55937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TOMM22 56993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TMEM42  
Two-hybrid Homo sapiens
31 CHRNB2  
Affinity Capture-MS Homo sapiens
32 SPCS1 28972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TMEM243  
Two-hybrid Homo sapiens
34 CYB5R3 1727
Co-fractionation Homo sapiens
35 HARS2 23438
Affinity Capture-MS Homo sapiens
36 NCLN 56926
Affinity Capture-MS Homo sapiens
37 VAMP1 6843
Two-hybrid Homo sapiens
38 PCSK9 255738
Affinity Capture-MS Homo sapiens
39 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
40 CHRNE  
Affinity Capture-MS Homo sapiens
41 PPAPDC2  
Two-hybrid Homo sapiens
42 UBE2J1 51465
Two-hybrid Homo sapiens
43 SERP1 27230
Two-hybrid Homo sapiens
44 PRSS23 11098
Two-hybrid Homo sapiens
45 MFF 56947
Two-hybrid Homo sapiens
46 TREX1  
Two-hybrid Homo sapiens
47 SPCS2 9789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CCDC47 57003
Affinity Capture-MS Homo sapiens
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