Gene description for FUNDC2
Gene name FUN14 domain containing 2
Gene symbol FUNDC2
Other names/aliases DC44
HCBP6
HCC3
PD03104
Species Homo sapiens
 Database cross references - FUNDC2
ExoCarta ExoCarta_65991
Vesiclepedia VP_65991
Entrez Gene 65991
HGNC 24925
UniProt Q9BWH2  
 FUNDC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FUNDC2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
Biological Process
    autophagy of mitochondrion GO:0000422 IBA
    regulation of platelet activation GO:0010543 ISS
    intracellular triglyceride homeostasis GO:0035356 IMP
Subcellular Localization
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IBA
 Experiment description of studies that identified FUNDC2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FUNDC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD13C  
Affinity Capture-MS Homo sapiens
2 SERPINB4 6318
Affinity Capture-MS Homo sapiens
3 MTCH1 23787
Proximity Label-MS Homo sapiens
4 SLC10A6  
Two-hybrid Homo sapiens
5 DHCR24 1718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PQLC1  
Two-hybrid Homo sapiens
7 USP13  
Two-hybrid Homo sapiens
8 ATP13A2  
Two-hybrid Homo sapiens
9 NACA 4666
Two-hybrid Homo sapiens
10 ARL15 54622
Two-hybrid Homo sapiens
11 HK3  
Affinity Capture-MS Homo sapiens
12 MFN1 55669
Affinity Capture-MS Homo sapiens
13 ANXA8 653145
Affinity Capture-MS Homo sapiens
14 RGS1  
Two-hybrid Homo sapiens
15 CD79A  
Two-hybrid Homo sapiens
16 SLC16A10 117247
Two-hybrid Homo sapiens
17 COX20  
Two-hybrid Homo sapiens
18 SLC18A2  
Affinity Capture-MS Homo sapiens
19 TMEM154  
Two-hybrid Homo sapiens
20 ALDH1A1 216
Affinity Capture-MS Homo sapiens
21 COQ9  
Affinity Capture-MS Homo sapiens
22 STOM 2040
Two-hybrid Homo sapiens
23 CIDEB  
Two-hybrid Homo sapiens
24 SYT2  
Two-hybrid Homo sapiens
25 HIATL1 84641
Two-hybrid Homo sapiens
26 SLC25A46 91137
Proximity Label-MS Homo sapiens
27 SEC11C 90701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TP53I3  
Two-hybrid Homo sapiens
29 SERPINA1 5265
Affinity Capture-MS Homo sapiens
30 KIR2DL3  
Two-hybrid Homo sapiens
31 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FCER1G 2207
Two-hybrid Homo sapiens
33 MTCH2 23788
Proximity Label-MS Homo sapiens
34 REEP4  
Two-hybrid Homo sapiens
35 IFITM3 10410
Affinity Capture-MS Homo sapiens
36 FUNDC2 65991
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 FUNDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 FUNDC2P2  
Affinity Capture-MS Homo sapiens
39 EVI2B 2124
Two-hybrid Homo sapiens
40 IGHG1 3500
Affinity Capture-MS Homo sapiens
41 ASCC2 84164
Two-hybrid Homo sapiens
42 KCNJ6  
Two-hybrid Homo sapiens
43 ARL13B 200894
Two-hybrid Homo sapiens
44 CALML5 51806
Affinity Capture-MS Homo sapiens
45 RHOT2 89941
Proximity Label-MS Homo sapiens
46 DNAJC7 7266
Affinity Capture-MS Homo sapiens
47 CALML3 810
Affinity Capture-MS Homo sapiens
48 SERPINB3 6317
Affinity Capture-MS Homo sapiens
49 TYMP 1890
Affinity Capture-MS Homo sapiens
50 FGF14  
Two-hybrid Homo sapiens
51 EIF6 3692
Two-hybrid Homo sapiens
52 GPX1 2876
Affinity Capture-MS Homo sapiens
53 CRB3 92359
Two-hybrid Homo sapiens
54 IGKC 3514
Affinity Capture-MS Homo sapiens
55 GOLT1B 51026
Affinity Capture-MS Homo sapiens
56 TMEM128  
Affinity Capture-MS Homo sapiens
57 S100A7 6278
Affinity Capture-MS Homo sapiens
58 S100A7A 338324
Affinity Capture-MS Homo sapiens
59 OCIAD1 54940
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
60 NXF1 10482
Affinity Capture-RNA Homo sapiens
61 GPR152  
Two-hybrid Homo sapiens
62 MAPK6  
Affinity Capture-MS Homo sapiens
63 IST1 9798
Affinity Capture-MS Homo sapiens
64 FAM134C 162427
Two-hybrid Homo sapiens
65 CMTM5  
Affinity Capture-MS Homo sapiens
66 LGALS7B 653499
Affinity Capture-MS Homo sapiens
67 METTL9 51108
Affinity Capture-MS Homo sapiens
68 AKAP1 8165
Proximity Label-MS Homo sapiens
69 TMX2 51075
Two-hybrid Homo sapiens
70 NUDT21 11051
Two-hybrid Homo sapiens
71 MZB1  
Affinity Capture-MS Homo sapiens
72 RNASE7 84659
Affinity Capture-MS Homo sapiens
73 NSF 4905
Two-hybrid Homo sapiens
74 SDR16C5  
Two-hybrid Homo sapiens
75 TMEM68  
Affinity Capture-MS Homo sapiens
76 IGHG2 3501
Affinity Capture-MS Homo sapiens
77 EBP  
Two-hybrid Homo sapiens
78 SAT1  
Two-hybrid Homo sapiens
79 SHMT2 6472
Affinity Capture-RNA Homo sapiens
80 ERGIC2 51290
Affinity Capture-MS Homo sapiens
81 MOV10 4343
Affinity Capture-RNA Homo sapiens
82 BCL2L1 598
Affinity Capture-MS Homo sapiens
83 GLUL 2752
Affinity Capture-MS Homo sapiens
84 SEC62 7095
Affinity Capture-MS Homo sapiens
85 CYB5R3 1727
Affinity Capture-MS Homo sapiens
86 IFITM1 8519
Affinity Capture-MS Homo sapiens
87 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 MGST3 4259
Two-hybrid Homo sapiens
89 C20orf141  
Affinity Capture-MS Homo sapiens
90 INTU  
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which FUNDC2 is involved
No pathways found





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