Gene description for RNASE7
Gene name ribonuclease, RNase A family, 7
Gene symbol RNASE7
Other names/aliases -
Species Homo sapiens
 Database cross references - RNASE7
ExoCarta ExoCarta_84659
Entrez Gene 84659
HGNC 19278
MIM 612484
UniProt Q9H1E1  
 RNASE7 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
 Gene ontology annotations for RNASE7
Molecular Function
    lipopolysaccharide binding GO:0001530 IDA
    ribonuclease activity GO:0004540 IDA
    endonuclease activity GO:0004519 IBA
    peptidoglycan binding GO:0042834 IDA
    nucleic acid binding GO:0003676 IEA
Biological Process
    innate immune response GO:0045087 NAS
    antibacterial humoral response GO:0019731 IDA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IBA
    RNA phosphodiester bond hydrolysis GO:0090501 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to Gram-negative bacterium GO:0050829 IDA
    response to bacterium GO:0009617 NAS
    membrane disruption in other organism GO:0051673 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified RNASE7 in exosomes
1
Experiment ID 76
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|GAPDH|HSP90
EV Cytosolic markers
✔
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
✔
HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
 Protein-protein interactions for RNASE7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RNASE7 is involved
No pathways found





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