Gene description for MTHFD2L
Gene name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Gene symbol MTHFD2L
Other names/aliases -
Species Homo sapiens
 Database cross references - MTHFD2L
ExoCarta ExoCarta_441024
Entrez Gene 441024
HGNC 31865
MIM 614047
UniProt Q9H903  
 MTHFD2L identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MTHFD2L
Molecular Function
    methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IBA
    formate-tetrahydrofolate ligase activity GO:0004329 IBA
    methenyltetrahydrofolate cyclohydrolase activity GO:0004477 IBA
    methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487 IBA
Biological Process
    one-carbon metabolic process GO:0006730 IBA
    oxidation-reduction process GO:0055114 IEA
    purine nucleotide biosynthetic process GO:0006164 IEA
    tetrahydrofolate interconversion GO:0035999 IEA
    folic acid-containing compound biosynthetic process GO:0009396 IEA
    methionine biosynthetic process GO:0009086 IEA
    histidine biosynthetic process GO:0000105 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrion GO:0005739 IBA
 Experiment description of studies that identified MTHFD2L in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MTHFD2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MTHFD2L is involved
No pathways found





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