Gene description for NUDT3
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 3
Gene symbol NUDT3
Other names/aliases DIPP
DIPP-1
DIPP1
Species Homo sapiens
 Database cross references - NUDT3
ExoCarta ExoCarta_11165
Vesiclepedia VP_11165
Entrez Gene 11165
HGNC 8050
MIM 609228
UniProt O95989  
 NUDT3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NUDT3
Molecular Function
    magnesium ion binding GO:0000287 IDA
    endopolyphosphatase activity GO:0000298 IBA
    endopolyphosphatase activity GO:0000298 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    diphosphoinositol-polyphosphate diphosphatase activity GO:0008486 IBA
    diphosphoinositol-polyphosphate diphosphatase activity GO:0008486 IDA
    manganese ion binding GO:0030145 IDA
    bis(5'-adenosyl)-hexaphosphatase activity GO:0034431 IBA
    bis(5'-adenosyl)-pentaphosphatase activity GO:0034432 IBA
    inositol diphosphate tetrakisphosphate diphosphatase activity GO:0052840 IDA
    inositol diphosphate tetrakisphosphate diphosphatase activity GO:0052840 IMP
    inositol diphosphate pentakisphosphate diphosphatase activity GO:0052842 IDA
    inositol diphosphate pentakisphosphate diphosphatase activity GO:0052842 IMP
    inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity GO:0052845 IEA
    inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity GO:0052848 IEA
    5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity GO:0140932 IDA
    5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity GO:0140933 IDA
Biological Process
    cell-cell signaling GO:0007267 TAS
    diadenosine polyphosphate catabolic process GO:0015961 TAS
    diphosphoinositol polyphosphate metabolic process GO:0071543 IBA
    diphosphoinositol polyphosphate catabolic process GO:0071544 IDA
    RNA decapping GO:0110154 IDA
    RNA decapping GO:0110154 IMP
    diadenosine pentaphosphate catabolic process GO:1901907 IBA
    diadenosine hexaphosphate catabolic process GO:1901909 IBA
    diadenosine hexaphosphate catabolic process GO:1901909 IDA
    adenosine 5'-(hexahydrogen pentaphosphate) catabolic process GO:1901911 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified NUDT3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NUDT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 CAPNS2 84290
Affinity Capture-MS Homo sapiens
3 SERPINB4 6318
Affinity Capture-MS Homo sapiens
4 NUDT10  
Affinity Capture-MS Homo sapiens
5 EEF1G 1937
Two-hybrid Homo sapiens
6 IL36G 56300
Affinity Capture-MS Homo sapiens
7 SERPINB13 5275
Affinity Capture-MS Homo sapiens
8 CCL11  
Two-hybrid Homo sapiens
9 CSTA 1475
Affinity Capture-MS Homo sapiens
10 MVK 4598
Co-fractionation Homo sapiens
11 ARL6IP1 23204
Two-hybrid Homo sapiens
12 AZGP1 563
Affinity Capture-MS Homo sapiens
13 ALOX12B  
Affinity Capture-MS Homo sapiens
14 APOD 347
Affinity Capture-MS Homo sapiens
15 YTHDF2 51441
Co-fractionation Homo sapiens
16 APEX1 328
Two-hybrid Homo sapiens
17 ITFG1 81533
Two-hybrid Homo sapiens
18 GSDMA 284110
Affinity Capture-MS Homo sapiens
19 WDR74 54663
Two-hybrid Homo sapiens
20 ACPP 55
Affinity Capture-MS Homo sapiens
21 Ttll7  
Affinity Capture-MS Mus musculus
22 SOX30  
Two-hybrid Homo sapiens
23 KPRP 448834
Affinity Capture-MS Homo sapiens
24 NR2C1  
Two-hybrid Homo sapiens
25 TUBA1A 7846
Two-hybrid Homo sapiens
26 RNF126  
Two-hybrid Homo sapiens
27 Naa15 74838
Affinity Capture-MS Mus musculus
28 CTSV 1515
Affinity Capture-MS Homo sapiens
29 AP1S2 8905
Affinity Capture-MS Homo sapiens
30 ALAS1  
Two-hybrid Homo sapiens
31 RAB17 64284
Two-hybrid Homo sapiens
32 S100A2 6273
Affinity Capture-MS Homo sapiens
33 POF1B 79983
Affinity Capture-MS Homo sapiens
34 VPS51 738
Two-hybrid Homo sapiens
35 CHCHD3 54927
Two-hybrid Homo sapiens
36 TUBGCP4 27229
Two-hybrid Homo sapiens
37 SH3GL3  
Affinity Capture-MS Homo sapiens
38 MAPKAPK3 7867
Co-fractionation Homo sapiens
39 ARG1 383
Affinity Capture-MS Homo sapiens
40 PDCD5 9141
Two-hybrid Homo sapiens
41 S100A8 6279
Affinity Capture-MS Homo sapiens
42 DNAJA1 3301
Two-hybrid Homo sapiens
43 SPRR1B 6699
Affinity Capture-MS Homo sapiens
44 RPLP1 6176
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
45 TGM1 7051
Affinity Capture-MS Homo sapiens
46 SERPINB7 8710
Affinity Capture-MS Homo sapiens
47 SERPINA3 12
Affinity Capture-MS Homo sapiens
48 ENAH 55740
Co-fractionation Homo sapiens
49 DBN1 1627
Two-hybrid Homo sapiens
50 REEP5 7905
Two-hybrid Homo sapiens
51 CALML3 810
Affinity Capture-MS Homo sapiens
52 NOTCH2NL 388677
Affinity Capture-MS Homo sapiens
53 ROGDI 79641
Affinity Capture-MS Homo sapiens
54 IMPA2 3613
Affinity Capture-MS Homo sapiens
55 SPRR1A  
Affinity Capture-MS Homo sapiens
56 SERPINB3 6317
Affinity Capture-MS Homo sapiens
57 IVL 3713
Affinity Capture-MS Homo sapiens
58 PITRM1 10531
Co-fractionation Homo sapiens
59 MAF1  
Two-hybrid Homo sapiens
60 IQCB1  
Affinity Capture-MS Homo sapiens
61 S100A7 6278
Affinity Capture-MS Homo sapiens
62 RPL8 6132
Two-hybrid Homo sapiens
63 S100A7A 338324
Affinity Capture-MS Homo sapiens
64 BAIAP2L1 55971
Co-fractionation Homo sapiens
65 PRKD3 23683
Two-hybrid Homo sapiens
66 NXF1 10482
Affinity Capture-RNA Homo sapiens
67 A2ML1 144568
Affinity Capture-MS Homo sapiens
68 UBR1 197131
Two-hybrid Homo sapiens
69 MEX3B 84206
Two-hybrid Homo sapiens
70 HSPA1A 3303
Affinity Capture-MS Homo sapiens
71 SDR9C7  
Affinity Capture-MS Homo sapiens
72 FOXK1 221937
Co-fractionation Homo sapiens
73 RNASE7 84659
Affinity Capture-MS Homo sapiens
74 JUP 3728
Affinity Capture-MS Homo sapiens
75 MCM5 4174
Two-hybrid Homo sapiens
76 ASB13  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
77 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
78 S100A9 6280
Affinity Capture-MS Homo sapiens
79 OAT 4942
Two-hybrid Homo sapiens
80 MOV10 4343
Affinity Capture-RNA Homo sapiens
81 GLUL 2752
Affinity Capture-MS Homo sapiens
82 GM2A 2760
Affinity Capture-MS Homo sapiens
83 DDR1 780
Two-hybrid Homo sapiens
84 HES1 3280
Two-hybrid Homo sapiens
85 NCCRP1 342897
Affinity Capture-MS Homo sapiens
86 PEX5 5830
Two-hybrid Homo sapiens
87 LCN2 3934
Affinity Capture-MS Homo sapiens
88 FXYD3 5349
Two-hybrid Homo sapiens
89 WARS 7453
Co-fractionation Homo sapiens
90 TNNT3  
Two-hybrid Homo sapiens
91 NUDT5 11164
Two-hybrid Homo sapiens
92 RPL17 6139
Two-hybrid Homo sapiens
93 XPNPEP1 7511
Two-hybrid Homo sapiens
94 CTSH 1512
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUDT3 is involved
PathwayEvidenceSource
Inositol phosphate metabolism TAS Reactome
Metabolism TAS Reactome
Synthesis of pyrophosphates in the cytosol TAS Reactome





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