Gene description for PRKD3
Gene name protein kinase D3
Gene symbol PRKD3
Other names/aliases EPK2
PKC-NU
PKD3
PRKCN
nPKC-NU
Species Homo sapiens
 Database cross references - PRKD3
ExoCarta ExoCarta_23683
Entrez Gene 23683
HGNC 9408
MIM 607077
UniProt O94806  
 PRKD3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PRKD3
Molecular Function
    metal ion binding GO:0046872 IEA
    protein kinase C activity GO:0004697 IEA
    kinase activity GO:0016301 IDA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
Biological Process
    protein phosphorylation GO:0006468 IEA
    intracellular signal transduction GO:0035556 IEA
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PRKD3 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PRKD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRKD3 is involved
No pathways found





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