Gene description for EXTL3
Gene name exostosin-like glycosyltransferase 3
Gene symbol EXTL3
Other names/aliases BOTV
EXTL1L
EXTR1
REGR
RPR
Species Homo sapiens
 Database cross references - EXTL3
ExoCarta ExoCarta_2137
Vesiclepedia VP_2137
Entrez Gene 2137
HGNC 3518
MIM 605744
UniProt O43909  
 EXTL3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EXTL3
Molecular Function
    magnesium ion binding GO:0000287 IDA
    glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0001888 IDA
    protein binding GO:0005515 IPI
    protein-hormone receptor activity GO:0016500 IDA
    protein-hormone receptor activity GO:0016500 ISS
    glycosyltransferase activity GO:0016757 IBA
    glycosyltransferase activity GO:0016757 IDA
Biological Process
    protein glycosylation GO:0006486 IEA
    positive regulation of keratinocyte proliferation GO:0010838 IDA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IDA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IEA
    positive regulation of cell growth GO:0030307 IEA
    negative regulation of keratinocyte differentiation GO:0045617 IDA
    negative regulation of inflammatory response GO:0050728 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    negative regulation of inflammatory response to wounding GO:0106015 IDA
    negative regulation of cytokine production involved in inflammatory response GO:1900016 ISS
    positive regulation of detection of glucose GO:2000972 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified EXTL3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EXTL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 CMAS 55907
Affinity Capture-MS Homo sapiens
3 XIAP  
Affinity Capture-Western Homo sapiens
4 CHRNA4  
Affinity Capture-MS Homo sapiens
5 PAEP  
Affinity Capture-MS Homo sapiens
6 GALNT1 2589
Affinity Capture-MS Homo sapiens
7 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CFC1  
Affinity Capture-MS Homo sapiens
9 NDUFB5 4711
Affinity Capture-MS Homo sapiens
10 TMEM95  
Affinity Capture-MS Homo sapiens
11 SYNE4  
Affinity Capture-MS Homo sapiens
12 SLURP1  
Affinity Capture-MS Homo sapiens
13 SLC22A9  
Affinity Capture-MS Homo sapiens
14 TOMM22 56993
Affinity Capture-MS Homo sapiens
15 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 NDUFB8 4714
Affinity Capture-MS Homo sapiens
17 ADCY6 112
Affinity Capture-MS Homo sapiens
18 CLEC2B  
Affinity Capture-MS Homo sapiens
19 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 INO80E  
Affinity Capture-MS Homo sapiens
21 TMEM192 201931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TOMM40 10452
Affinity Capture-MS Homo sapiens
23 NDUFV3 4731
Affinity Capture-MS Homo sapiens
24 TMEM259 91304
Affinity Capture-MS Homo sapiens
25 BTNL2  
Affinity Capture-MS Homo sapiens
26 TMEM106A  
Affinity Capture-MS Homo sapiens
27 NDUFA6  
Affinity Capture-MS Homo sapiens
28 KCNA4  
Affinity Capture-MS Homo sapiens
29 CD70 970
Affinity Capture-MS Homo sapiens
30 NDUFS4 4724
Affinity Capture-MS Homo sapiens
31 IKBIP 121457
Affinity Capture-MS Homo sapiens
32 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 APLP2 334
Affinity Capture-MS Homo sapiens
34 PPP6R2 9701
Affinity Capture-MS Homo sapiens
35 P2RY8  
Affinity Capture-MS Homo sapiens
36 KDSR 2531
Affinity Capture-MS Homo sapiens
37 SDF2L1 23753
Affinity Capture-MS Homo sapiens
38 CCDC85C  
Affinity Capture-MS Homo sapiens
39 S1PR1 1901
Affinity Capture-MS Homo sapiens
40 C1orf54  
Affinity Capture-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 ANGPT4  
Affinity Capture-MS Homo sapiens
43 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PDGFRA 5156
Affinity Capture-MS Homo sapiens
45 ZACN  
Affinity Capture-MS Homo sapiens
46 CHRND  
Affinity Capture-MS Homo sapiens
47 SV2C  
Affinity Capture-MS Homo sapiens
48 C7orf34  
Affinity Capture-MS Homo sapiens
49 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SV2A 9900
Affinity Capture-MS Homo sapiens
51 th  
Affinity Capture-Western Drosophila melanogaster
52 CXCR4 7852
Affinity Capture-MS Homo sapiens
53 MSH2 4436
Affinity Capture-MS Homo sapiens
54 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ND5 4540
Affinity Capture-MS Homo sapiens
56 ADCY9 115
Affinity Capture-MS Homo sapiens
57 PON2 5445
Affinity Capture-MS Homo sapiens
58 CHRNA1  
Affinity Capture-MS Homo sapiens
59 PRG2  
Affinity Capture-MS Homo sapiens
60 LYZL1  
Affinity Capture-MS Homo sapiens
61 HTR2C  
Affinity Capture-MS Homo sapiens
62 LAMB3 3914
Affinity Capture-MS Homo sapiens
63 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PRKD3 23683
Affinity Capture-MS Homo sapiens
65 PLEKHA5 54477
Two-hybrid Homo sapiens
66 SYP  
Affinity Capture-MS Homo sapiens
67 EXT1 2131
Affinity Capture-MS Homo sapiens
68 NDUFB3 4709
Affinity Capture-MS Homo sapiens
69 B3GAT3 26229
Affinity Capture-MS Homo sapiens
70 CST9L  
Affinity Capture-MS Homo sapiens
71 PODXL 5420
Affinity Capture-MS Homo sapiens
72 ADAM10 102
Affinity Capture-MS Homo sapiens
73 NRG1 3084
Affinity Capture-MS Homo sapiens
74 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
75 GLRA2  
Affinity Capture-MS Homo sapiens
76 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
77 GP9 2815
Affinity Capture-MS Homo sapiens
78 LDLRAD1  
Affinity Capture-MS Homo sapiens
79 CD1A 909
Affinity Capture-MS Homo sapiens
80 TSPAN15 23555
Affinity Capture-MS Homo sapiens
81 NDUFA12 55967
Affinity Capture-MS Homo sapiens
82 THAP11 57215
Affinity Capture-MS Homo sapiens
83 CLEC12B  
Affinity Capture-MS Homo sapiens
84 PLD3 23646
Affinity Capture-MS Homo sapiens
85 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
86 BRICD5  
Affinity Capture-MS Homo sapiens
87 EXT2 2132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 GOLGA5 9950
Affinity Capture-MS Homo sapiens
89 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SLC39A5 283375
Affinity Capture-MS Homo sapiens
91 DEFA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 ADGRE5 976
Affinity Capture-MS Homo sapiens
93 GOLM1 51280
Affinity Capture-MS Homo sapiens
94 HTR1B  
Affinity Capture-MS Homo sapiens
95 SLC1A1 6505
Affinity Capture-MS Homo sapiens
96 ND4 4538
Affinity Capture-MS Homo sapiens
97 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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