Gene description for S1PR1
Gene name sphingosine-1-phosphate receptor 1
Gene symbol S1PR1
Other names/aliases CD363
CHEDG1
D1S3362
ECGF1
EDG-1
EDG1
S1P1
Species Homo sapiens
 Database cross references - S1PR1
ExoCarta ExoCarta_1901
Vesiclepedia VP_1901
Entrez Gene 1901
HGNC 3165
MIM 601974
UniProt P21453  
 S1PR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for S1PR1
Molecular Function
    G protein-coupled receptor binding GO:0001664 IPI
    G protein-coupled receptor activity GO:0004930 TAS
    protein binding GO:0005515 IPI
    sphingosine-1-phosphate receptor activity GO:0038036 IBA
    sphingosine-1-phosphate receptor activity GO:0038036 IDA
    sphingolipid binding GO:0046625 IEA
Biological Process
    angiogenesis GO:0001525 IBA
    blood vessel maturation GO:0001955 ISS
    cardiac muscle tissue growth involved in heart morphogenesis GO:0003245 ISS
    sphingosine-1-phosphate receptor signaling pathway GO:0003376 IBA
    sphingosine-1-phosphate receptor signaling pathway GO:0003376 IDA
    chemotaxis GO:0006935 ISS
    cell adhesion GO:0007155 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IEA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    brain development GO:0007420 IEA
    cell population proliferation GO:0008283 IEA
    cell migration GO:0016477 ISS
    regulation of metabolic process GO:0019222 IBA
    transmission of nerve impulse GO:0019226 IEA
    lamellipodium assembly GO:0030032 ISS
    actin cytoskeleton organization GO:0030036 ISS
    regulation of cell adhesion GO:0030155 IEA
    neuron differentiation GO:0030182 IEA
    positive regulation of cell migration GO:0030335 IEA
    regulation of bone mineralization GO:0030500 ISS
    leukocyte chemotaxis GO:0030595 IEA
    regulation of bone resorption GO:0045124 ISS
    endothelial cell differentiation GO:0045446 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    positive regulation of positive chemotaxis GO:0050927 IEA
    negative regulation of stress fiber assembly GO:0051497 IEA
    heart trabecula morphogenesis GO:0061384 ISS
    T cell migration GO:0072678 IDA
    T cell migration GO:0072678 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    endosome GO:0005768 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    membrane raft GO:0045121 IEA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified S1PR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for S1PR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CMTM6 54918
Affinity Capture-MS Homo sapiens
2 SLC39A10 57181
Affinity Capture-MS Homo sapiens
3 SACM1L 22908
Affinity Capture-MS Homo sapiens
4 TTYH3 80727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC39A4 55630
Affinity Capture-MS Homo sapiens
6 IPO7 10527
Affinity Capture-MS Homo sapiens
7 KIAA2013 90231
Affinity Capture-MS Homo sapiens
8 TMED5 50999
Affinity Capture-MS Homo sapiens
9 HK3  
Affinity Capture-MS Homo sapiens
10 ATP12A 479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TSG101 7251
Affinity Capture-MS Homo sapiens
12 HRAS 3265
Affinity Capture-MS Homo sapiens
13 GNAQ 2776
Affinity Capture-MS Homo sapiens
14 LMBR1  
Affinity Capture-MS Homo sapiens
15 TTYH2 94015
Affinity Capture-MS Homo sapiens
16 C1orf112  
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
19 POTEF 728378
Affinity Capture-MS Homo sapiens
20 PTDSS2 81490
Affinity Capture-MS Homo sapiens
21 MON2 23041
Affinity Capture-MS Homo sapiens
22 SRC 6714
Affinity Capture-MS Homo sapiens
23 TM9SF1 10548
Affinity Capture-MS Homo sapiens
24 YIPF3 25844
Affinity Capture-MS Homo sapiens
25 PPP6R1 22870
Affinity Capture-MS Homo sapiens
26 RER1 11079
Affinity Capture-MS Homo sapiens
27 C10orf35  
Affinity Capture-MS Homo sapiens
28 ATP2A3 489
Affinity Capture-MS Homo sapiens
29 IPO8 10526
Affinity Capture-MS Homo sapiens
30 TBC1D15 64786
Affinity Capture-MS Homo sapiens
31 GNAI1 2770
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
32 STXBP3 6814
Affinity Capture-MS Homo sapiens
33 NDUFAF1  
Affinity Capture-MS Homo sapiens
34 BTAF1 9044
Affinity Capture-MS Homo sapiens
35 GPRIN1 114787
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ATP1A3 478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PPM1B 5495
Affinity Capture-MS Homo sapiens
38 EXTL3 2137
Affinity Capture-MS Homo sapiens
39 POMGNT1 55624
Affinity Capture-MS Homo sapiens
40 CNNM4 26504
Affinity Capture-MS Homo sapiens
41 TMEM126A 84233
Affinity Capture-MS Homo sapiens
42 PDGFRB 5159
Affinity Capture-Western Homo sapiens
43 TSPAN3 10099
Affinity Capture-MS Homo sapiens
44 ZMYM3  
Affinity Capture-MS Homo sapiens
45 ACP2 53
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MKRN2 23609
Affinity Capture-RNA Homo sapiens
47 TNPO2 30000
Affinity Capture-MS Homo sapiens
48 CYBA 1535
Affinity Capture-MS Homo sapiens
49 MRS2  
Affinity Capture-MS Homo sapiens
50 CKAP5 9793
Affinity Capture-MS Homo sapiens
51 IL10RA  
Negative Genetic Homo sapiens
52 TMEM259 91304
Affinity Capture-MS Homo sapiens
53 GNA13 10672
Affinity Capture-MS Homo sapiens
54 CHCHD6 84303
Affinity Capture-MS Homo sapiens
55 ATP2C1 27032
Affinity Capture-MS Homo sapiens
56 RHOT2 89941
Affinity Capture-MS Homo sapiens
57 GNG5 2787
Affinity Capture-MS Homo sapiens
58 ARL10  
Affinity Capture-MS Homo sapiens
59 TMED1 11018
Affinity Capture-MS Homo sapiens
60 RMDN3 55177
Affinity Capture-MS Homo sapiens
61 IPO9 55705
Affinity Capture-MS Homo sapiens
62 RAP2A 5911
Affinity Capture-MS Homo sapiens
63 TTI1 9675
Affinity Capture-MS Homo sapiens
64 FANCD2  
Affinity Capture-MS Homo sapiens
65 TMEM160 54958
Affinity Capture-MS Homo sapiens
66 TNPO3 23534
Affinity Capture-MS Homo sapiens
67 GBF1 8729
Affinity Capture-MS Homo sapiens
68 FRMD5 84978
Affinity Capture-MS Homo sapiens
69 TM9SF3 56889
Affinity Capture-MS Homo sapiens
70 SLC38A10 124565
Affinity Capture-MS Homo sapiens
71 SAAL1 113174
Affinity Capture-MS Homo sapiens
72 XPO4 64328
Affinity Capture-MS Homo sapiens
73 VPS37A 137492
Affinity Capture-MS Homo sapiens
74 CMSS1  
Two-hybrid Homo sapiens
75 TMCO1 54499
Affinity Capture-MS Homo sapiens
76 ITPRIPL1  
Affinity Capture-MS Homo sapiens
77 ACAD9 28976
Affinity Capture-MS Homo sapiens
78 PKD2 5311
Affinity Capture-MS Homo sapiens
79 CERS6  
Affinity Capture-MS Homo sapiens
80 DYM  
Affinity Capture-MS Homo sapiens
81 THADA 63892
Affinity Capture-MS Homo sapiens
82 STX17 55014
Affinity Capture-MS Homo sapiens
83 IRF3 3661
Negative Genetic Homo sapiens
84 ATP2B3 492
Affinity Capture-MS Homo sapiens
85 TRIP6 7205
Affinity Capture-Western Homo sapiens
86 COLEC12 81035
Affinity Capture-MS Homo sapiens
87 VPS28 51160
Affinity Capture-MS Homo sapiens
88 GPR180  
Affinity Capture-MS Homo sapiens
89 MCL1 4170
Positive Genetic Homo sapiens
90 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 COX16  
Affinity Capture-MS Homo sapiens
92 CD47 961
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TSPAN15 23555
Affinity Capture-MS Homo sapiens
94 B4GAT1 11041
Affinity Capture-MS Homo sapiens
95 HTR1D  
Affinity Capture-Western Homo sapiens
96 CAV1 857
Affinity Capture-Western Homo sapiens
97 WWP2 11060
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
98 ERGIC2 51290
Affinity Capture-MS Homo sapiens
99 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
100 SORT1 6272
Affinity Capture-MS Homo sapiens
101 ATP2B2 491
Affinity Capture-MS Homo sapiens
102 RELB  
Negative Genetic Homo sapiens
103 AGPAT6 137964
Affinity Capture-MS Homo sapiens
104 GNAI3 2773
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
105 CKAP4 10970
Affinity Capture-MS Homo sapiens
106 THEM6  
Affinity Capture-MS Homo sapiens
107 ECSIT 51295
Affinity Capture-MS Homo sapiens
108 HTR1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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