Gene description for TMEM126A
Gene name transmembrane protein 126A
Gene symbol TMEM126A
Other names/aliases OPA7
Species Homo sapiens
 Database cross references - TMEM126A
ExoCarta ExoCarta_84233
Vesiclepedia VP_84233
Entrez Gene 84233
HGNC 25382
MIM 612988
UniProt Q9H061  
 TMEM126A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM126A
Biological Process
    optic nerve development GO:0021554 IMP
    protein insertion into mitochondrial inner membrane from matrix GO:0032979 IDA
    mitochondrial respiratory chain complex I assembly GO:0032981 IBA
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    toll-like receptor 4 signaling pathway GO:0034142 IEA
    mitochondrial protein quality control GO:0141164 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified TMEM126A in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM126A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 ZWINT  
Affinity Capture-MS Homo sapiens
4 LYPD3 27076
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 FAM73A  
Affinity Capture-MS Homo sapiens
7 COLEC12 81035
Affinity Capture-MS Homo sapiens
8 Hax1  
Affinity Capture-MS Mus musculus
9 APLNR  
Affinity Capture-MS Homo sapiens
10 Rad54l  
Affinity Capture-MS Mus musculus
11 TACR1  
Affinity Capture-MS Homo sapiens
12 TSPAN15 23555
Affinity Capture-MS Homo sapiens
13 SLC25A3 5250
Co-fractionation Homo sapiens
14 VIPR1  
Affinity Capture-MS Homo sapiens
15 KIF14 9928
Affinity Capture-MS Homo sapiens
16 Tuba3a 22144
Affinity Capture-MS Mus musculus
17 FFAR1  
Affinity Capture-MS Homo sapiens
18 GLMN 11146
Affinity Capture-MS Homo sapiens
19 IPO7 10527
Affinity Capture-MS Homo sapiens
20 APOO 79135
Proximity Label-MS Homo sapiens
21 EFNA2  
Affinity Capture-MS Homo sapiens
22 KCNK1  
Affinity Capture-MS Homo sapiens
23 SLC1A1 6505
Affinity Capture-MS Homo sapiens
24 SLC39A4 55630
Affinity Capture-MS Homo sapiens
25 LPAR2 9170
Affinity Capture-MS Homo sapiens
26 LAMB1 3912
Affinity Capture-MS Homo sapiens
27 STRN3 29966
Affinity Capture-MS Homo sapiens
28 SMC6  
Affinity Capture-MS Homo sapiens
29 MBOAT1  
Affinity Capture-MS Homo sapiens
30 LRRC73  
Affinity Capture-MS Homo sapiens
31 TGM2 7052
Affinity Capture-MS Homo sapiens
32 NDUFA4 4697
Affinity Capture-MS Homo sapiens
33 SRSF2 6427
Co-fractionation Homo sapiens
34 SAAL1 113174
Affinity Capture-MS Homo sapiens
35 SRSF3 6428
Co-fractionation Homo sapiens
36 LPAR1 1902
Affinity Capture-MS Homo sapiens
37 SASS6 163786
Affinity Capture-MS Homo sapiens
38 SSBP1 6742
Co-fractionation Homo sapiens
39 DUSP6 1848
Affinity Capture-MS Homo sapiens
40 PCBP4 57060
Affinity Capture-MS Homo sapiens
41 SFXN1 94081
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
42 LOC100132735  
Protein-RNA Homo sapiens
43 ADK 132
Cross-Linking-MS (XL-MS) Homo sapiens
44 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
45 DUSP12 11266
Affinity Capture-MS Homo sapiens
46 GPR52  
Affinity Capture-MS Homo sapiens
47 PIGN 23556
Affinity Capture-MS Homo sapiens
48 FBXO6 26270
Affinity Capture-MS Homo sapiens
49 RPA3 6119
Proximity Label-MS Homo sapiens
50 TMEM79  
Affinity Capture-MS Homo sapiens
51 CDK4 1019
Affinity Capture-MS Homo sapiens
52 SPPL2B 56928
Affinity Capture-MS Homo sapiens
53 S1PR1 1901
Affinity Capture-MS Homo sapiens
54 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
55 ACKR2  
Affinity Capture-MS Homo sapiens
56 GPR182  
Affinity Capture-MS Homo sapiens
57 CHCHD2  
Affinity Capture-MS Homo sapiens
58 PARP1 142
Proximity Label-MS Homo sapiens
59 EDNRA 1909
Affinity Capture-MS Homo sapiens
60 EYA3  
Affinity Capture-MS Homo sapiens
61 LRBA 987
Affinity Capture-MS Homo sapiens
62 DIAPH3 81624
Affinity Capture-MS Homo sapiens
63 SLC6A5  
Affinity Capture-MS Homo sapiens
64 C1orf210  
Affinity Capture-MS Homo sapiens
65 TMEM63A 9725
Affinity Capture-MS Homo sapiens
66 DUSP2  
Affinity Capture-MS Homo sapiens
67 TMEM182  
Affinity Capture-MS Homo sapiens
68 MRPS22 56945
Co-fractionation Homo sapiens
69 EWSR1 2130
Co-fractionation Homo sapiens
70 DNAJC30  
Proximity Label-MS Homo sapiens
71 PARD6A  
Affinity Capture-MS Homo sapiens
72 TNFSF18 8995
Affinity Capture-MS Homo sapiens
73 HAUS7  
Affinity Capture-MS Homo sapiens
74 C9orf72  
Affinity Capture-MS Homo sapiens
75 TBC1D15 64786
Affinity Capture-MS Homo sapiens
76 KCNE4  
Affinity Capture-MS Homo sapiens
77 SMPD1 6609
Affinity Capture-MS Homo sapiens
78 ARMC6 93436
Affinity Capture-MS Homo sapiens
79 KRBOX4  
Affinity Capture-MS Homo sapiens
80 COX4I1 1327
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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