Gene description for PCBP4
Gene name poly(rC) binding protein 4
Gene symbol PCBP4
Other names/aliases CBP
LIP4
MCG10
Species Homo sapiens
 Database cross references - PCBP4
ExoCarta ExoCarta_57060
Entrez Gene 57060
HGNC 8652
MIM 608503
UniProt P57723  
 PCBP4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PCBP4
Molecular Function
    RNA binding GO:0003723 NAS
    poly(A) RNA binding GO:0044822 IDA
    DNA binding GO:0003677 IEA
Biological Process
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IEA
Subcellular Localization
    ribonucleoprotein complex GO:0030529 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PCBP4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PCBP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PCBP4 is involved
No pathways found





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