Gene description for TXNDC8
Gene name thioredoxin domain containing 8 (spermatozoa)
Gene symbol TXNDC8
Other names/aliases SPTRX-3
TRX6
bA427L11.2
Species Homo sapiens
 Database cross references - TXNDC8
ExoCarta ExoCarta_255220
Entrez Gene 255220
HGNC 31454
UniProt Q6A555  
 TXNDC8 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TXNDC8
Molecular Function
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 IBA
    protein disulfide oxidoreductase activity GO:0015035 IDA
Biological Process
    oxidation-reduction process GO:0055114 IBA
    cellular response to oxidative stress GO:0034599 IBA
    acrosome assembly GO:0001675 IEA
    protein folding GO:0006457 IBA
    glycerol ether metabolic process GO:0006662 IEA
    sulfate assimilation GO:0000103 IBA
    multicellular organismal development GO:0007275 IEA
    cell redox homeostasis GO:0045454 IBA
    spermatogenesis GO:0007283 IEP
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IBA
    acrosomal vesicle GO:0001669 IEA
    cytoplasm GO:0005737 IDA
    sperm flagellum GO:0036126 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified TXNDC8 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TXNDC8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TXNDC8 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here