Gene description for RBFOX1
Gene name RNA binding protein, fox-1 homolog (C. elegans) 1
Gene symbol RBFOX1
Other names/aliases 2BP1
A2BP1
FOX-1
FOX1
HRNBP1
Species Homo sapiens
 Database cross references - RBFOX1
ExoCarta ExoCarta_54715
Vesiclepedia VP_54715
Entrez Gene 54715
HGNC 18222
MIM 605104
UniProt Q9NWB1  
 RBFOX1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RBFOX1
Molecular Function
    RNA binding GO:0003723 NAS
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IBA
    mRNA processing GO:0006397 IEA
    nervous system development GO:0007399 IBA
    RNA splicing GO:0008380 IEA
    RNA transport GO:0050658 NAS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    trans-Golgi network GO:0005802 IDA
    cytoplasmic stress granule GO:0010494 IDA
    nuclear stress granule GO:0097165 IDA
 Experiment description of studies that identified RBFOX1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RBFOX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAPNS2 84290
Affinity Capture-MS Homo sapiens
2 ATXN1 6310
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 ALG13 79868
Two-hybrid Homo sapiens
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 TNIP1 10318
Two-hybrid Homo sapiens
6 MKRN1 23608
Affinity Capture-MS Homo sapiens
7 SPRTN  
Affinity Capture-MS Homo sapiens
8 RBFOX2 23543
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
9 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 ILF3 3609
Affinity Capture-RNA Homo sapiens
11 DVL2 1856
Two-hybrid Homo sapiens
12 GCA 25801
Two-hybrid Homo sapiens
13 PRR20A  
Two-hybrid Homo sapiens
14 CTSV 1515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RBM24 221662
Two-hybrid Homo sapiens
16 DMRTB1  
Two-hybrid Homo sapiens
17 ATXN2 6311
Two-hybrid Homo sapiens
18 IL1B  
Affinity Capture-RNA Homo sapiens
19 HSFX1  
Two-hybrid Homo sapiens
20 RNF25 64320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 QKI 9444
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 TSNAX 7257
Affinity Capture-MS Homo sapiens
23 CELF3  
Two-hybrid Homo sapiens
24 DAB1 1600
Two-hybrid Homo sapiens
25 DAZAP2  
Two-hybrid Homo sapiens
26 BHLHE40  
Two-hybrid Homo sapiens
27 FAM168A  
Two-hybrid Homo sapiens
28 RBFOX1 54715
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 KLC1 3831
Affinity Capture-MS Homo sapiens
30 RHOXF2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
31 C1orf94  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 KIFAP3 22920
Two-hybrid Homo sapiens
33 PKP1 5317
Affinity Capture-MS Homo sapiens
34 SOX2  
Affinity Capture-MS Homo sapiens
35 RIOK1 83732
Affinity Capture-MS Homo sapiens
36 CRX  
Two-hybrid Homo sapiens
37 HSFY1  
Two-hybrid Homo sapiens
38 MAGED1 9500
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 LZTS2 84445
Two-hybrid Homo sapiens
40 CAPZB 832
Affinity Capture-MS Homo sapiens
41 PCBP4 57060
Two-hybrid Homo sapiens
42 NOC2L 26155
Two-hybrid Homo sapiens
43 ATN1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
44 RBFOX3  
Cross-Linking-MS (XL-MS) Homo sapiens
45 PRRC2A 7916
Two-hybrid Homo sapiens
46 NUMBL 9253
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
47 PSMF1 9491
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
48 PRMT5 10419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 HNRNPF 3185
Two-hybrid Homo sapiens
50 PLK4  
Affinity Capture-MS Homo sapiens
51 SNRPN 6638
Two-hybrid Homo sapiens
52 IMPA2 3613
Affinity Capture-MS Homo sapiens
53 COPRS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 KRAS 3845
Synthetic Lethality Homo sapiens
55 C9orf72  
Affinity Capture-MS Homo sapiens
56 GATAD1  
Affinity Capture-MS Homo sapiens
57 PHF12  
Affinity Capture-MS Homo sapiens
58 SDR9C7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BBS2 583
Affinity Capture-MS Homo sapiens
60 SERPINA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CLNS1A 1207
Affinity Capture-MS Homo sapiens
62 ECM1 1893
Affinity Capture-MS Homo sapiens
63 IL1A  
Affinity Capture-RNA Homo sapiens
64 TGM1 7051
Affinity Capture-MS Homo sapiens
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