Gene description for BBS2
Gene name Bardet-Biedl syndrome 2
Gene symbol BBS2
Other names/aliases BBS
Species Homo sapiens
 Database cross references - BBS2
ExoCarta ExoCarta_583
Vesiclepedia VP_583
Entrez Gene 583
HGNC 967
MIM 606151
UniProt Q9BXC9  
 BBS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BBS2
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II repressing transcription factor binding GO:0001103 IPI
Biological Process
    cilium assembly GO:0042384 IBA
    melanosome transport GO:0032402 ISS
    hippocampus development GO:0021766 ISS
    cilium morphogenesis GO:0060271 ISS
    striatum development GO:0021756 ISS
    sperm axoneme assembly GO:0007288 ISS
    cartilage development GO:0051216 IEA
    cerebral cortex development GO:0021987 ISS
    positive regulation of multicellular organism growth GO:0040018 IEA
    artery smooth muscle contraction GO:0014824 IEA
    photoreceptor cell maintenance GO:0045494 ISS
    negative regulation of gene expression GO:0010629 IEA
    regulation of cilium beat frequency involved in ciliary motility GO:0060296 ISS
    visual perception GO:0007601 IEA
    protein localization to organelle GO:0033365 ISS
    adult behavior GO:0030534 ISS
    Golgi to plasma membrane protein transport GO:0043001 IMP
    protein localization GO:0008104 ISS
    brain morphogenesis GO:0048854 ISS
    negative regulation of appetite by leptin-mediated signaling pathway GO:0038108 ISS
    negative regulation of multicellular organism growth GO:0040015 ISS
    fat cell differentiation GO:0045444 ISS
    protein localization to ciliary membrane GO:1903441 IBA
    vasodilation GO:0042311 IEA
    nonmotile primary cilium assembly GO:0035058 IEA
    organelle organization GO:0006996 TAS
Subcellular Localization
    membrane GO:0016020 IBA
    ciliary basal body GO:0036064 IDA
    motile cilium GO:0031514 IDA
    BBSome GO:0034464 IDA
    cytosol GO:0005829 TAS
    ciliary membrane GO:0060170 IEA
 Experiment description of studies that identified BBS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BBS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSME3 10197
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BBS2 is involved
PathwayEvidenceSource
BBSome-mediated cargo-targeting to cilium TAS Reactome





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