Gene description for C16orf59
Gene name chromosome 16 open reading frame 59
Gene symbol C16orf59
Other names/aliases -
Species Homo sapiens
 Database cross references - C16orf59
ExoCarta ExoCarta_80178
Vesiclepedia VP_80178
Entrez Gene 80178
HGNC 25849
UniProt Q7L2K0  
 C16orf59 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for C16orf59
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of smoothened signaling pathway GO:0045880 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centriole GO:0005814 ISS
    cilium GO:0005929 ISS
 Experiment description of studies that identified C16orf59 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for C16orf59
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NOTCH2NL 388677
Two-hybrid Homo sapiens
4 FEZ1  
Two-hybrid Homo sapiens
5 KNSTRN  
Affinity Capture-MS Homo sapiens
6 FEM1A  
Affinity Capture-MS Homo sapiens
7 TP53 7157
Negative Genetic Homo sapiens
8 MIS18A  
Two-hybrid Homo sapiens
9 MDFI  
Two-hybrid Homo sapiens
10 KRTAP10-3  
Two-hybrid Homo sapiens
11 RAI14 26064
Affinity Capture-MS Homo sapiens
12 KRT27 342574
Two-hybrid Homo sapiens
13 APEX1 328
Affinity Capture-RNA Homo sapiens
14 TUBE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KDM1A 23028
Two-hybrid Homo sapiens
16 OGT 8473
Reconstituted Complex Homo sapiens
17 Tube1  
Affinity Capture-MS Mus musculus
18 C14orf80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BBS2 583
Affinity Capture-MS Homo sapiens
20 LURAP1  
Affinity Capture-MS Homo sapiens
21 FEZ2 9637
Two-hybrid Homo sapiens
22 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C16orf59 is involved
No pathways found





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