Gene description for FEZ2
Gene name fasciculation and elongation protein zeta 2 (zygin II)
Gene symbol FEZ2
Other names/aliases HUM3CL
Species Homo sapiens
 Database cross references - FEZ2
ExoCarta ExoCarta_9637
Vesiclepedia VP_9637
Entrez Gene 9637
HGNC 3660
MIM 604826
UniProt Q9UHY8  
 FEZ2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FEZ2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 TAS
    nervous system development GO:0007399 TAS
    axon guidance GO:0007411 TAS
    negative regulation of autophagosome assembly GO:1902902 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    axon GO:0030424 IBA
 Experiment description of studies that identified FEZ2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FEZ2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPS7 51081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 FEZ1  
Two-hybrid Homo sapiens
3 SMC3 9126
Two-hybrid Homo sapiens
4 SNX27 81609
Affinity Capture-MS Homo sapiens
5 ADAMTS4  
Affinity Capture-MS Homo sapiens
6 CLASP2 23122
Two-hybrid Homo sapiens
7 SAP30L  
Two-hybrid Homo sapiens
8 TLK2  
Two-hybrid Homo sapiens
9 PPM1B 5495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
11 KIF6 221458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TTI1 9675
Affinity Capture-MS Homo sapiens
13 PRKCZ 5590
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 CUL3 8452
Affinity Capture-MS Homo sapiens
15 C2CD4B  
Affinity Capture-MS Homo sapiens
16 KPNA2 3838
Two-hybrid Homo sapiens
17 RAI14 26064
Two-hybrid Homo sapiens
18 NEK1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
19 DRAP1 10589
Two-hybrid Homo sapiens
20 DIRAS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 WWC1  
Two-hybrid Homo sapiens
22 BRD1 23774
Two-hybrid Homo sapiens
23 RAB3GAP1 22930
Two-hybrid Homo sapiens
24 RANBP1 5902
Affinity Capture-MS Homo sapiens
25 SCOC 60592
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
26 ZNF251  
Two-hybrid Homo sapiens
27 TRMT2A 27037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C16orf59 80178
Two-hybrid Homo sapiens
29 PDCD7  
Two-hybrid Homo sapiens
30 TBC1D25  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FEZ2 is involved
No pathways found





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