Gene description for TTI1
Gene name TELO2 interacting protein 1
Gene symbol TTI1
Other names/aliases KIAA0406
smg-10
Species Homo sapiens
 Database cross references - TTI1
ExoCarta ExoCarta_9675
Vesiclepedia VP_9675
Entrez Gene 9675
HGNC 29029
MIM 614425
UniProt O43156  
 TTI1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TTI1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of TOR signaling GO:0032006 IMP
    protein stabilization GO:0050821 NAS
    positive regulation of DNA damage checkpoint GO:2000003 IMP
    positive regulation of DNA damage checkpoint GO:2000003 NAS
Subcellular Localization
    nucleus GO:0005634 NAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    TORC1 complex GO:0031931 IDA
    TORC1 complex GO:0031931 IMP
    TORC2 complex GO:0031932 IDA
    TORC2 complex GO:0031932 IMP
    TTT Hsp90 cochaperone complex GO:0110078 IPI
 Experiment description of studies that identified TTI1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TTI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Proximity Label-MS Homo sapiens
2 ATR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 KLK15  
Affinity Capture-MS Homo sapiens
4 Ruvbl1 56505
Affinity Capture-MS Mus musculus
5 CD68 968
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 LPAR6  
Affinity Capture-MS Homo sapiens
8 ZNHIT2 741
Proximity Label-MS Homo sapiens
9 FPR1  
Affinity Capture-MS Homo sapiens
10 ATM 472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 CCDC42  
Affinity Capture-MS Homo sapiens
12 CLTB 1212
Proximity Label-MS Homo sapiens
13 FFAR1  
Affinity Capture-MS Homo sapiens
14 PRKDC 5591
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 POTEF 728378
Affinity Capture-MS Homo sapiens
16 KIAA1429 25962
Affinity Capture-MS Homo sapiens
17 RUVBL1 8607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 COPB2 9276
Co-fractionation Homo sapiens
19 TELO2 9894
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 GPR55  
Affinity Capture-MS Homo sapiens
21 POU5F1  
Affinity Capture-MS Homo sapiens
22 P2RY8  
Affinity Capture-MS Homo sapiens
23 TACSTD2 4070
Affinity Capture-MS Homo sapiens
24 ITFG3 83986
Affinity Capture-MS Homo sapiens
25 F2RL1  
Affinity Capture-MS Homo sapiens
26 RXFP4  
Two-hybrid Homo sapiens
27 NCSTN 23385
Affinity Capture-MS Homo sapiens
28 GPR17 2840
Affinity Capture-MS Homo sapiens
29 PROKR1  
Affinity Capture-MS Homo sapiens
30 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 Mgp 17313
Affinity Capture-MS Mus musculus
32 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 EFNA5  
Affinity Capture-MS Homo sapiens
34 RUFY1 80230
Co-fractionation Homo sapiens
35 STOM 2040
Affinity Capture-MS Homo sapiens
36 AGK 55750
Affinity Capture-MS Homo sapiens
37 COPG1 22820
Co-fractionation Homo sapiens
38 COMTD1 118881
Affinity Capture-MS Homo sapiens
39 PBXIP1 57326
Affinity Capture-MS Homo sapiens
40 S1PR1 1901
Affinity Capture-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 TSC22D1 8848
Co-fractionation Homo sapiens
43 ARL13B 200894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FEZ2 9637
Affinity Capture-MS Homo sapiens
45 CACNG4  
Affinity Capture-MS Homo sapiens
46 CD40 958
Affinity Capture-MS Homo sapiens
47 NTRK1 4914
Affinity Capture-MS Homo sapiens
48 EFNA4  
Affinity Capture-MS Homo sapiens
49 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NPTN 27020
Affinity Capture-MS Homo sapiens
51 POLR2E 5434
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
52 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MGARP  
Affinity Capture-MS Homo sapiens
54 CUL3 8452
Affinity Capture-MS Homo sapiens
55 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
57 FBXO6 26270
Affinity Capture-MS Homo sapiens
58 FKBP5 2289
Affinity Capture-MS Homo sapiens
59 C3orf18  
Affinity Capture-MS Homo sapiens
60 GPR45  
Affinity Capture-MS Homo sapiens
61 MTOR 2475
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 HSPA4 3308
Affinity Capture-MS Homo sapiens
63 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 P2RY10  
Affinity Capture-MS Homo sapiens
65 B3GALT5  
Affinity Capture-MS Homo sapiens
66 HERC1 8925
Affinity Capture-MS Homo sapiens
67 GYPA  
Affinity Capture-MS Homo sapiens
68 TMEM51 55092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
70 Ruvbl2 20174
Affinity Capture-MS Mus musculus
71 COPZ1 22818
Co-fractionation Homo sapiens
72 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MFSD4  
Affinity Capture-MS Homo sapiens
74 EFNB1 1947
Affinity Capture-MS Homo sapiens
75 HTR6  
Affinity Capture-MS Homo sapiens
76 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 NUP50 10762
Co-fractionation Homo sapiens
78 TTI2 80185
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 API5 8539
Co-fractionation Homo sapiens
80 HEATR5A 25938
Affinity Capture-MS Homo sapiens
81 SMG1 23049
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 PIH1D1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
83 VIPR1  
Affinity Capture-MS Homo sapiens
84 FPR2  
Affinity Capture-MS Homo sapiens
85 ARSF 416
Affinity Capture-MS Homo sapiens
86 PSME4 23198
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which TTI1 is involved
No pathways found





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