Gene description for TSC22D1
Gene name TSC22 domain family, member 1
Gene symbol TSC22D1
Other names/aliases Ptg-2
TGFB1I4
TSC22
Species Homo sapiens
 Database cross references - TSC22D1
ExoCarta ExoCarta_8848
Vesiclepedia VP_8848
Entrez Gene 8848
HGNC 16826
MIM 607715
UniProt Q15714  
 TSC22D1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSC22D1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    transcription coactivator activity GO:0003713 IMP
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IDA
Biological Process
    transcription by RNA polymerase II GO:0006366 TAS
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of apoptotic process GO:0043066 IBA
    positive regulation of programmed cell death GO:0043068 ISS
    negative regulation of programmed cell death GO:0043069 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    negative regulation of hematopoietic stem cell proliferation GO:1902034 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified TSC22D1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSC22D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APLP1 333
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 KMT2C 58508
Two-hybrid Homo sapiens
3 FBN3 84467
Two-hybrid Homo sapiens
4 QARS 5859
Two-hybrid Homo sapiens
5 HNRNPM 4670
Affinity Capture-MS Homo sapiens
6 WNK1 65125
Two-hybrid Homo sapiens
7 SRPRB 58477
Affinity Capture-MS Homo sapiens
8 ALB 213
Affinity Capture-MS Homo sapiens
9 CD2AP 23607
Co-fractionation Homo sapiens
10 RGS1  
Two-hybrid Homo sapiens
11 MAP3K12  
Two-hybrid Homo sapiens
12 PDHB 5162
Two-hybrid Homo sapiens
13 GCN1L1 10985
Affinity Capture-MS Homo sapiens
14 ADAM19 8728
Affinity Capture-MS Homo sapiens
15 CCDC90B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 TGFBR1 7046
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
18 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 COPB2 9276
Affinity Capture-MS Homo sapiens
20 NCOA5  
Two-hybrid Homo sapiens
21 NUP93 9688
Affinity Capture-MS Homo sapiens
22 CARHSP1 23589
Two-hybrid Homo sapiens
23 BMPR1B 658
Affinity Capture-Western Homo sapiens
24 FAF1 11124
Two-hybrid Homo sapiens
25 EED  
Two-hybrid Homo sapiens
26 WIZ 58525
Two-hybrid Homo sapiens
27 CHD3 1107
Two-hybrid Homo sapiens
28 ACVR1 90
Affinity Capture-Western Homo sapiens
29 FAM20C 56975
Two-hybrid Homo sapiens
30 DHDH  
Affinity Capture-MS Homo sapiens
31 LRIF1  
Two-hybrid Homo sapiens
32 TAF5L  
Two-hybrid Homo sapiens
33 EMC1 23065
Affinity Capture-MS Homo sapiens
34 UNK  
Affinity Capture-RNA Homo sapiens
35 TSC22D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 WDR73  
Two-hybrid Homo sapiens
37 LARP7 51574
Co-fractionation Homo sapiens
38 A2M 2
Two-hybrid Homo sapiens
39 GNB5 10681
Two-hybrid Homo sapiens
40 BAG6 7917
Affinity Capture-MS Homo sapiens
41 SNRNP200 23020
Co-fractionation Homo sapiens
42 RPL5 6125
Two-hybrid Homo sapiens
43 ACVR1B 91
Affinity Capture-Western Homo sapiens
44 SP110  
Two-hybrid Homo sapiens
45 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
46 FAM24B  
Affinity Capture-MS Homo sapiens
47 GORASP2 26003
Two-hybrid Homo sapiens
48 CTNNB1 1499
Affinity Capture-MS Homo sapiens
49 UNC119 9094
Two-hybrid Homo sapiens
50 IARS 3376
Affinity Capture-MS Homo sapiens
51 CRMP1 1400
Two-hybrid Homo sapiens
52 WDYHV1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 DDAH2 23564
Two-hybrid Homo sapiens
54 MTR 4548
Affinity Capture-MS Homo sapiens
55 PTN  
Two-hybrid Homo sapiens
56 TTI1 9675
Co-fractionation Homo sapiens
57 CACNA1A  
Two-hybrid Homo sapiens
58 C14orf1 11161
Two-hybrid Homo sapiens
59 NDUFA9 4704
Affinity Capture-MS Homo sapiens
60 ACVRL1 94
Affinity Capture-Western Homo sapiens
61 ASAH1 427
Two-hybrid Homo sapiens
62 SLC25A22  
Affinity Capture-MS Homo sapiens
63 EPPK1 83481
Affinity Capture-MS Homo sapiens
64 C9orf9  
Two-hybrid Homo sapiens
65 ZC3HC1  
Two-hybrid Homo sapiens
66 PRKCI 5584
Two-hybrid Homo sapiens
67 CDK2 1017
Affinity Capture-MS Homo sapiens
68 NRBP1 29959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CORO2B 10391
Two-hybrid Homo sapiens
70 DNMT3B  
Two-hybrid Homo sapiens
71 RPA3 6119
Affinity Capture-MS Homo sapiens
72 GNB2 2783
Two-hybrid Homo sapiens
73 GSTK1 373156
Affinity Capture-MS Homo sapiens
74 TCEB2 6923
Affinity Capture-MS Homo sapiens
75 SMAD6  
Affinity Capture-Western Homo sapiens
76 MCM3AP  
Two-hybrid Homo sapiens
77 SETDB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 UBE2D1 7321
Two-hybrid Homo sapiens
79 IKBKAP 8518
Co-fractionation Homo sapiens
80 CA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 TGFBR2 7048
Affinity Capture-Western Homo sapiens
82 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
83 TP53 7157
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
84 KMT2B  
Two-hybrid Homo sapiens
85 SPRED1 161742
Two-hybrid Homo sapiens
86 TLE1 7088
Two-hybrid Homo sapiens
87 DNAAF5 54919
Affinity Capture-MS Homo sapiens
88 BMPR1A 657
Affinity Capture-Western Homo sapiens
89 OTUB1 55611
Two-hybrid Homo sapiens
90 SFXN1 94081
Affinity Capture-MS Homo sapiens
91 HMGXB4 10042
Two-hybrid Homo sapiens
92 NUP50 10762
Co-fractionation Homo sapiens
93 TSC22D1 8848
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 VIM 7431
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TSC22D1 is involved
No pathways found





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