Gene description for TSC22D1
Gene name TSC22 domain family, member 1
Gene symbol TSC22D1
Other names/aliases Ptg-2
TGFB1I4
TSC22
Species Homo sapiens
 Database cross references - TSC22D1
ExoCarta ExoCarta_8848
Vesiclepedia VP_8848
Entrez Gene 8848
HGNC 16826
MIM 607715
UniProt Q15714  
 TSC22D1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSC22D1
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    positive regulation of apoptotic process GO:0043065 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified TSC22D1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSC22D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTR 4548
Affinity Capture-MS Homo sapiens
2 APLP1 333
Two-hybrid Homo sapiens
3 HNRNPM 4670
Affinity Capture-MS Homo sapiens
4 SFXN1 94081
Affinity Capture-MS Homo sapiens
5 EMC1 23065
Affinity Capture-MS Homo sapiens
6 NDUFA9 4704
Affinity Capture-MS Homo sapiens
7 SRPRB 58477
Affinity Capture-MS Homo sapiens
8 ASAH1 427
Two-hybrid Homo sapiens
9 SLC25A22  
Affinity Capture-MS Homo sapiens
10 EPPK1 83481
Affinity Capture-MS Homo sapiens
11 DNAAF5 54919
Affinity Capture-MS Homo sapiens
12 RGS1  
Two-hybrid Homo sapiens
13 MAP3K12  
Two-hybrid Homo sapiens
14 GCN1L1 10985
Affinity Capture-MS Homo sapiens
15 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
16 MDS025  
Two-hybrid Homo sapiens
17 CDK2 1017
Affinity Capture-MS Homo sapiens
18 NRBP1 29959
Affinity Capture-MS Homo sapiens
19 CORO2B 10391
Two-hybrid Homo sapiens
20 TSC22D1 8848
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 RPA3 6119
Affinity Capture-MS Homo sapiens
22 BAG6 7917
Affinity Capture-MS Homo sapiens
23 GSTK1 373156
Affinity Capture-MS Homo sapiens
24 COPB2 9276
Affinity Capture-MS Homo sapiens
25 NUP93 9688
Affinity Capture-MS Homo sapiens
26 IARS 3376
Affinity Capture-MS Homo sapiens
27 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TSC22D1 is involved
No pathways found





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