Gene description for ACVR1B
Gene name
activin A receptor, type IB
Gene symbol
ACVR1B
Other names/aliases
ACTRIB ACVRLK4 ALK4 SKR2
Species
Homo sapiens
Database cross references - ACVR1B
ExoCarta
ExoCarta_91
Entrez Gene
91
HGNC
172
MIM
601300
UniProt
P36896
ACVR1B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for ACVR1B
Experiment description of studies that identified ACVR1B in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for ACVR1B
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
INHBB
3625
Affinity Capture-Western
Homo sapiens
2
ACVR1
90
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
3
SNX1
6642
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
SNX2
6643
Invivo
Homo sapiens
5
TDGF1
Invivo
Homo sapiens
6
Smad7
Affinity Capture-Western
Mus musculus
7
ACVR2A
Invivo
Homo sapiens
8
BMPR2
659
Two-hybrid
Homo sapiens
9
SMAD4
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
10
ACVR2B
Invivo
Homo sapiens
Co-purification
Homo sapiens
11
SMAD7
Affinity Capture-Western
Homo sapiens
12
INHBA
3624
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
13
TGFBRAP1
9392
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which ACVR1B is involved