Gene description for ACVR1B
Gene name	activin A receptor, type IB
Gene symbol	ACVR1B
Other names/aliases	ACTRIB ACVRLK4 ALK4 SKR2
Species	Homo sapiens
Database cross references - ACVR1B
ExoCarta	ExoCarta_91
Entrez Gene	91
HGNC	172
MIM	601300
UniProt	P36896
ACVR1B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for ACVR1B

Molecular Function     metal ion binding GO:0046872 IEA     transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS     activin receptor activity, type I GO:0016361 TAS     growth factor binding GO:0019838 IPI     activin binding GO:0048185 IDA     receptor signaling protein serine/threonine kinase activity GO:0004702 IEA     protein serine/threonine kinase activity GO:0004674 IDA     ubiquitin protein ligase binding GO:0031625 NAS     ATP binding GO:0005524 IDA     activin-activated receptor activity GO:0017002 IDA     protein binding GO:0005515 IPI     SMAD binding GO:0046332 IDA     inhibin binding GO:0034711 IPI Biological Process     development of primary female sexual characteristics GO:0046545 IEA     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IEA     protein phosphorylation GO:0006468 IDA     signal transduction by protein phosphorylation GO:0023014 IEA     in utero embryonic development GO:0001701 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of activin receptor signaling pathway GO:0032927 IDA     extrinsic apoptotic signaling pathway GO:0097191 IMP     negative regulation of cell growth GO:0030308 IDA     regulation of transcription, DNA-templated GO:0006355 IDA     nodal signaling pathway GO:0038092 IGI     hair follicle development GO:0001942 IEA     G1/S transition of mitotic cell cycle GO:0000082 IDA     peptidyl-threonine phosphorylation GO:0018107 IDA     transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 TAS     protein autophosphorylation GO:0046777 IDA     activin receptor signaling pathway GO:0032924 IMP     negative regulation of gene expression GO:0010629 IEA     positive regulation of erythrocyte differentiation GO:0045648 IDA     positive regulation of trophoblast cell migration GO:1901165 IDA     signal transduction GO:0007165 IDA     central nervous system development GO:0007417 IEA Subcellular Localization     activin receptor complex GO:0048179 IDA     integral component of plasma membrane GO:0005887 IDA     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     receptor complex GO:0043235 IDA