Gene description for ACVR1B
Gene name activin A receptor, type IB
Gene symbol ACVR1B
Other names/aliases ACTRIB
ACVRLK4
ALK4
SKR2
Species Homo sapiens
 Database cross references - ACVR1B
ExoCarta ExoCarta_91
Entrez Gene 91
HGNC 172
MIM 601300
UniProt P36896  
 ACVR1B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ACVR1B
Molecular Function
    metal ion binding GO:0046872 IEA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    activin receptor activity, type I GO:0016361 TAS
    growth factor binding GO:0019838 IPI
    activin binding GO:0048185 IDA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    ubiquitin protein ligase binding GO:0031625 NAS
    ATP binding GO:0005524 IDA
    activin-activated receptor activity GO:0017002 IDA
    protein binding GO:0005515 IPI
    SMAD binding GO:0046332 IDA
    inhibin binding GO:0034711 IPI
Biological Process
    development of primary female sexual characteristics GO:0046545 IEA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IEA
    protein phosphorylation GO:0006468 IDA
    signal transduction by protein phosphorylation GO:0023014 IEA
    in utero embryonic development GO:0001701 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    positive regulation of activin receptor signaling pathway GO:0032927 IDA
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    negative regulation of cell growth GO:0030308 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    nodal signaling pathway GO:0038092 IGI
    hair follicle development GO:0001942 IEA
    G1/S transition of mitotic cell cycle GO:0000082 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 TAS
    protein autophosphorylation GO:0046777 IDA
    activin receptor signaling pathway GO:0032924 IMP
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of erythrocyte differentiation GO:0045648 IDA
    positive regulation of trophoblast cell migration GO:1901165 IDA
    signal transduction GO:0007165 IDA
    central nervous system development GO:0007417 IEA
Subcellular Localization
    activin receptor complex GO:0048179 IDA
    integral component of plasma membrane GO:0005887 IDA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified ACVR1B in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACVR1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INHBB 3625
Affinity Capture-Western Homo sapiens
2 ACVR1 90
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
3 SNX1 6642
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 SNX2 6643
Invivo Homo sapiens
5 TDGF1  
Invivo Homo sapiens
6 Smad7  
Affinity Capture-Western Mus musculus
7 ACVR2A  
Invivo Homo sapiens
8 BMPR2 659
Two-hybrid Homo sapiens
9 SMAD4  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACVR2B  
Invivo Homo sapiens
Co-purification Homo sapiens
11 SMAD7  
Affinity Capture-Western Homo sapiens
12 INHBA 3624
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
13 TGFBRAP1 9392
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ACVR1B is involved
PathwayEvidenceSource
Regulation of signaling by NODAL TAS Reactome
Signaling by Activin TAS Reactome
Signaling by NODAL TAS Reactome





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