Gene description for INHBA
Gene name inhibin, beta A
Gene symbol INHBA
Other names/aliases EDF
FRP
Species Homo sapiens
 Database cross references - INHBA
ExoCarta ExoCarta_3624
Vesiclepedia VP_3624
Entrez Gene 3624
HGNC 6066
MIM 147290
UniProt P08476  
 INHBA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for INHBA
Molecular Function
    cytokine activity GO:0005125 IBA
    cytokine activity GO:0005125 IDA
    hormone activity GO:0005179 TAS
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 TAS
    peptide hormone binding GO:0017046 IPI
    identical protein binding GO:0042802 IPI
    protein-containing complex binding GO:0044877 IEA
    type II activin receptor binding GO:0070699 IPI
Biological Process
    ovarian follicle development GO:0001541 IGI
    ovarian follicle development GO:0001541 NAS
    hair follicle development GO:0001942 IGI
    hematopoietic progenitor cell differentiation GO:0002244 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    transcription by RNA polymerase II GO:0006366 IEA
    autophagy GO:0006914 IEA
    defense response GO:0006952 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    cell-cell signaling GO:0007267 TAS
    nervous system development GO:0007399 NAS
    androgen metabolic process GO:0008209 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    male gonad development GO:0008584 IGI
    response to wounding GO:0009611 TAS
    positive regulation of gene expression GO:0010628 IDA
    cytokine-mediated signaling pathway GO:0019221 IEA
    striatal medium spiny neuron differentiation GO:0021773 IDA
    cell differentiation GO:0030154 TAS
    erythrocyte differentiation GO:0030218 NAS
    negative regulation of cell growth GO:0030308 IDA
    negative regulation of type II interferon production GO:0032689 TAS
    activin receptor signaling pathway GO:0032924 IDA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    endodermal cell differentiation GO:0035987 IDA
    negative regulation of phosphorylation GO:0042326 TAS
    odontogenesis GO:0042476 IGI
    hemoglobin biosynthetic process GO:0042541 IDA
    progesterone secretion GO:0042701 IGI
    negative regulation of B cell differentiation GO:0045578 TAS
    positive regulation of erythrocyte differentiation GO:0045648 IDA
    negative regulation of macrophage differentiation GO:0045650 TAS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase III GO:0045945 IEA
    regulation of follicle-stimulating hormone secretion GO:0046880 IGI
    positive regulation of follicle-stimulating hormone secretion GO:0046881 TAS
    negative regulation of follicle-stimulating hormone secretion GO:0046882 NAS
    mesodermal cell differentiation GO:0048333 IEA
    positive regulation of protein metabolic process GO:0051247 IDA
    Sertoli cell differentiation GO:0060008 IEA
    roof of mouth development GO:0060021 IGI
    positive regulation of ovulation GO:0060279 ISS
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    SMAD protein signal transduction GO:0060395 IEA
    cardiac fibroblast cell development GO:0060936 IEA
    eyelid development in camera-type eye GO:0061029 ISS
    testosterone biosynthetic process GO:0061370 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEA
    cellular response to cholesterol GO:0071397 IEA
    cellular response to hypoxia GO:0071456 IEA
    cellular response to oxygen-glucose deprivation GO:0090650 IEA
    GABAergic neuron differentiation GO:0097154 IDA
    extrinsic apoptotic signaling pathway GO:0097191 IDA
    androst-4-ene-3,17-dione biosynthetic process GO:1903449 IEA
    response to aldosterone GO:1904044 IEA
    cellular response to angiotensin GO:1904385 IEA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IDA
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    activin A complex GO:0043509 IDA
    inhibin A complex GO:0043512 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    enzyme activator complex GO:0150005 IDA
 Experiment description of studies that identified INHBA in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 189
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 190
MISEV standards
EM
Biophysical techniques
HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for INHBA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GINM1 116254
Affinity Capture-MS Homo sapiens
2 IGSF1  
Co-localization Homo sapiens
3 INSIG1  
Affinity Capture-MS Homo sapiens
4 CHRDL2 25884
Reconstituted Complex Homo sapiens
5 HMGCL 3155
Co-fractionation Homo sapiens
6 FST 10468
Co-crystal Structure Homo sapiens
7 IDH2 3418
Co-fractionation Homo sapiens
8 ACVR2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 ACVR1B 91
Affinity Capture-Western Homo sapiens
10 FABP3 2170
Co-fractionation Homo sapiens
11 ACVR2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 ALDH4A1 8659
Co-fractionation Homo sapiens
13 INSIG2  
Affinity Capture-MS Homo sapiens
14 ACVR1 90
Affinity Capture-Western Homo sapiens
15 MSRB2  
Co-fractionation Homo sapiens
16 LYPLAL1 127018
Co-fractionation Homo sapiens
17 ACVRL1 94
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here