Gene description for ACVR1
Gene name activin A receptor, type I
Gene symbol ACVR1
Other names/aliases ACTRI
ACVR1A
ACVRLK2
ALK2
FOP
SKR1
TSRI
Species Homo sapiens
 Database cross references - ACVR1
ExoCarta ExoCarta_90
Vesiclepedia VP_90
Entrez Gene 90
HGNC 171
MIM 102576
UniProt Q04771  
 ACVR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for ACVR1
Molecular Function
    activin binding GO:0048185 IDA
    transforming growth factor beta receptor activity, type I GO:0005025 IEA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    peptide hormone binding GO:0017046 NAS
    SMAD binding GO:0046332 IDA
    protein binding GO:0005515 IPI
    protein kinase activity GO:0004672 IDA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    transforming growth factor beta binding GO:0050431 IDA
    protein serine/threonine kinase activity GO:0004674 IDA
    metal ion binding GO:0046872 IEA
    protein homodimerization activity GO:0042803 IDA
    ATP binding GO:0005524 IDA
    activin receptor activity, type I GO:0016361 IDA
Biological Process
    regulation of ossification GO:0030278 IMP
    germ cell development GO:0007281 IEA
    determination of left/right symmetry GO:0007368 IEA
    positive regulation of determination of dorsal identity GO:2000017 IDA
    cellular response to glucocorticoid stimulus GO:0071385 IEA
    embryonic heart tube morphogenesis GO:0003143 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    signal transduction by protein phosphorylation GO:0023014 IEA
    atrial septum primum morphogenesis GO:0003289 IMP
    regulation of skeletal muscle tissue development GO:0048641 IEA
    positive regulation of bone mineralization GO:0030501 IMP
    protein phosphorylation GO:0006468 IDA
    negative regulation of signal transduction GO:0009968 IMP
    BMP signaling pathway GO:0030509 IDA
    gastrulation with mouth forming second GO:0001702 IEA
    acute inflammatory response GO:0002526 IEA
    urogenital system development GO:0001655 IEA
    negative regulation of activin receptor signaling pathway GO:0032926 IMP
    patterning of blood vessels GO:0001569 IEA
    smooth muscle cell differentiation GO:0051145 IEA
    cardiac muscle cell fate commitment GO:0060923 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    neural crest cell migration GO:0001755 IEA
    mitral valve morphogenesis GO:0003183 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    activin receptor signaling pathway GO:0032924 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    pharyngeal system development GO:0060037 IEA
    pathway-restricted SMAD protein phosphorylation GO:0060389 IDA
    mesoderm formation GO:0001707 IEA
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    endocardial cushion cell fate commitment GO:0061445 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    in utero embryonic development GO:0001701 IEA
Subcellular Localization
    activin receptor complex GO:0048179 IDA
    integral component of plasma membrane GO:0005887 IDA
    apical part of cell GO:0045177 IEA
 Experiment description of studies that identified ACVR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 260
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|FLOT1|CD81
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 231
MISEV standards
✘ EV Biophysical techniques
✔
Alix|CD63|CD9
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 232
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 233
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACVR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
2 SMAD5 4090
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
3 GDF5 8200
Affinity Capture-Western Homo sapiens
4 Rab6b  
Affinity Capture-Luminescence Mus musculus
5 Ube2e3  
Affinity Capture-Luminescence Mus musculus
6 Ap2b1 71770
Affinity Capture-Luminescence Mus musculus
7 Nras 18176
Affinity Capture-Luminescence Mus musculus
8 Fbxo3  
Affinity Capture-Luminescence Mus musculus
9 Uhmk1  
Affinity Capture-Luminescence Mus musculus
10 Rab17  
Affinity Capture-Luminescence Mus musculus
11 ENG 2022
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
12 Plek  
Affinity Capture-Luminescence Mus musculus
13 BMP7 655
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
14 Rab3b  
Affinity Capture-Luminescence Mus musculus
15 Usp21  
Affinity Capture-Luminescence Mus musculus
16 FNTA 2339
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
17 Nkiras1  
Affinity Capture-Luminescence Mus musculus
18 Fancl  
Affinity Capture-Luminescence Mus musculus
19 Rhoj  
Affinity Capture-Luminescence Mus musculus
20 Fkbp4 14228
Affinity Capture-Luminescence Mus musculus
21 Stat1 20846
Affinity Capture-Luminescence Mus musculus
22 Rras2 66922
Affinity Capture-Luminescence Mus musculus
23 SMAD1 4086
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
24 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
25 Stx8 55943
Affinity Capture-Luminescence Mus musculus
26 Ilkap  
Affinity Capture-Luminescence Mus musculus
27 ACVR1B 91
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
28 BMPR2 659
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
29 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
30 5830461H18Rik  
Affinity Capture-Luminescence Mus musculus
31 SMAD9  
Affinity Capture-MS Homo sapiens
32 Wdr61  
Affinity Capture-Luminescence Mus musculus
33 Ube2r2  
Affinity Capture-Luminescence Mus musculus
34 Rhod  
Affinity Capture-Luminescence Mus musculus
35 Jub  
Affinity Capture-Luminescence Mus musculus
36 Pftk1  
Affinity Capture-Luminescence Mus musculus
37 Sqstm1  
Affinity Capture-Luminescence Mus musculus
38 Rasd2  
Affinity Capture-Luminescence Mus musculus
39 Chn1  
Affinity Capture-Luminescence Mus musculus
40 Rab33b  
Affinity Capture-Luminescence Mus musculus
41 Rhebl1  
Affinity Capture-Luminescence Mus musculus
42 Ikbkb 16150
Affinity Capture-Luminescence Mus musculus
43 Plekhb1  
Affinity Capture-Luminescence Mus musculus
44 Fgd6  
Affinity Capture-Luminescence Mus musculus
45 NAA20  
Affinity Capture-Luminescence Mus musculus
46 Fcho1  
Affinity Capture-Luminescence Mus musculus
47 INHBA 3624
Affinity Capture-MS Homo sapiens
48 Usp39  
Affinity Capture-Luminescence Mus musculus
49 1200013B22Rik  
Affinity Capture-Luminescence Mus musculus
View the network image/svg+xml
 Pathways in which ACVR1 is involved
No pathways found





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