Experiment description of studies that identified ACVR1 in exosomes

1 Experiment ID 260 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101 EV Cytosolic markers ✔ FLOT1|CD81 EV Membrane markers ✘ EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25950383     Organism Homo sapiens Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L Journal name Pigment Cell Melanoma Res Publication year 2015 Sample Melanoma cells Sample name 1205Lu Isolation/purification methods Differential centrifugation Unltracentrifugation Sucrose density gradient Flotation density 1.13 - 1.19 g/mL Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

2 Experiment ID 231 ISEV standards ✘ EV Biophysical techniques ✔ Alix EV Cytosolic markers ✔ CD63|CD9 EV Membrane markers ✘ EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Lipids Methods used in the study Western blotting Mass spectrometry

3 Experiment ID 232 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✘ EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

4 Experiment ID 233 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✘ EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 3 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for ACVR1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 Rps27a 78294 Affinity Capture-Luminescence Mus musculus 2 SMAD5 4090 Invivo Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens 3 GDF5 8200 Affinity Capture-Western Homo sapiens 4 Rab6b   Affinity Capture-Luminescence Mus musculus 5 Ube2e3   Affinity Capture-Luminescence Mus musculus 6 Nras 18176 Affinity Capture-Luminescence Mus musculus 7 BMP7 655 Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens 8 Fbxo3   Affinity Capture-Luminescence Mus musculus 9 Uhmk1   Affinity Capture-Luminescence Mus musculus 10 Rab17   Affinity Capture-Luminescence Mus musculus 11 ENG 2022 Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 12 Tgfbr1   Affinity Capture-Luminescence Mus musculus 13 SMAD1   Invivo Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens 14 Rab3b   Affinity Capture-Luminescence Mus musculus 15 Usp21   Affinity Capture-Luminescence Mus musculus 16 FNTA 2339 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 17 Nkiras1   Affinity Capture-Luminescence Mus musculus 18 Fancl   Affinity Capture-Luminescence Mus musculus 19 Rhoj   Affinity Capture-Luminescence Mus musculus 20 Fkbp4 14228 Affinity Capture-Luminescence Mus musculus 21 Stat1 20846 Affinity Capture-Luminescence Mus musculus 22 Rras2 66922 Affinity Capture-Luminescence Mus musculus 23 Stx8 55943 Affinity Capture-Luminescence Mus musculus 24 Ilkap   Affinity Capture-Luminescence Mus musculus 25 ACVR1B 91 Invivo Homo sapiens Affinity Capture-MS Homo sapiens 26 BMPR2 659 Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 27 Rhobtb1   Affinity Capture-Luminescence Mus musculus 28 5830461H18Rik   Affinity Capture-Luminescence Mus musculus 29 SMAD9   Affinity Capture-MS Homo sapiens 30 Wdr61   Affinity Capture-Luminescence Mus musculus 31 Ap2b1   Affinity Capture-Luminescence Mus musculus 32 Ube2r2   Affinity Capture-Luminescence Mus musculus 33 Rhod   Affinity Capture-Luminescence Mus musculus 34 Jub   Affinity Capture-Luminescence Mus musculus 35 Pftk1   Affinity Capture-Luminescence Mus musculus 36 Sqstm1   Affinity Capture-Luminescence Mus musculus 37 Rasd2   Affinity Capture-Luminescence Mus musculus 38 Chn1   Affinity Capture-Luminescence Mus musculus 39 Rab33b   Affinity Capture-Luminescence Mus musculus 40 Rhebl1   Affinity Capture-Luminescence Mus musculus 41 Ikbkb 16150 Affinity Capture-Luminescence Mus musculus 42 Plekhb1   Affinity Capture-Luminescence Mus musculus 43 Fgd6   Affinity Capture-Luminescence Mus musculus 44 NAA20   Affinity Capture-Luminescence Mus musculus 45 Fcho1   Affinity Capture-Luminescence Mus musculus 46 INHBA 3624 Affinity Capture-MS Homo sapiens 47 Usp39   Affinity Capture-Luminescence Mus musculus 48 Plek   Affinity Capture-Luminescence Mus musculus 49 1200013B22Rik   Affinity Capture-Luminescence Mus musculus View the network

Pathways in which ACVR1 is involved

No pathways found