Gene description for Ikbkb
Gene name inhibitor of kappaB kinase beta
Gene symbol Ikbkb
Other names/aliases AI132552
IKK-2
IKK-beta
IKK2
IKK[b]
IKKbeta
Species Mus musculus
 Database cross references - Ikbkb
ExoCarta ExoCarta_16150
Entrez Gene 16150
UniProt O88351  
 Ikbkb identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ikbkb
Molecular Function
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    transferase activity GO:0016740 IEA
    protein heterodimerization activity GO:0046982 ISO
    receptor signaling protein serine/threonine kinase activity GO:0004702 TAS
    IkappaB kinase activity GO:0008384 IDA
    protein kinase binding GO:0019901 ISO
    protein homodimerization activity GO:0042803 ISO
    protein kinase activity GO:0004672 ISO
    scaffold protein binding GO:0097110 ISO
    ATP binding GO:0005524 ISO
    kinase activity GO:0016301 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    serine phosphorylation of STAT protein GO:0042501 ISO
    positive regulation of cation channel activity GO:2001259 IGI
    B cell homeostasis GO:0001782 IMP
    signal transduction by protein phosphorylation GO:0023014 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    phosphorylation GO:0016310 IEA
    protein phosphorylation GO:0006468 ISO
    I-kappaB phosphorylation GO:0007252 TAS
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of neuron death GO:1901216 ISO
    positive regulation of sodium ion transport GO:0010765 IGI
    neuron projection development GO:0031175 ISO
    cellular response to tumor necrosis factor GO:0071356 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    CD40 receptor complex GO:0035631 IDA
    membrane GO:0016020 IEA
    IkappaB kinase complex GO:0008385 ISO
    cytosol GO:0005829 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    cytoplasmic side of plasma membrane GO:0009898 IDA
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified Ikbkb in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ikbkb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR1 90
Affinity Capture-Luminescence Homo sapiens
2 TGFBR1  
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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