Gene description for Tnfrsf1a
Gene name tumor necrosis factor receptor superfamily, member 1a
Gene symbol Tnfrsf1a
Other names/aliases CD120a
FPF
TNF-R
TNF-R-I
TNF-R1
TNF-R55
TNF-alphaR1
TNFAR
TNFR60
TNFRI
TNFRp55
TNFalpha-R1
Tnfr-2
Tnfr1
p55
p55-R
Species Mus musculus
 Database cross references - Tnfrsf1a
ExoCarta ExoCarta_21937
Entrez Gene 21937
UniProt P25118  
 Tnfrsf1a identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Tnfrsf1a
Molecular Function
    protein complex binding GO:0032403 ISO
    tumor necrosis factor binding GO:0043120 ISO
    protein binding GO:0005515 IPI
    tumor necrosis factor-activated receptor activity GO:0005031 TAS
    protease binding GO:0002020 ISO
Biological Process
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISO
    positive regulation of inflammatory response GO:0050729 IMP
    cytokine-mediated signaling pathway GO:0019221 IMP
    inflammatory response GO:0006954 IMP
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of protein import into nucleus, translocation GO:0033160 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    signal transduction GO:0007165 IEA
    negative regulation of inflammatory response GO:0050728 ISO
    programmed cell death GO:0012501 IPI
    negative regulation of interleukin-6 production GO:0032715 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    apoptotic process GO:0006915 IEA
    protein heterooligomerization GO:0051291 ISO
    regulation of apoptotic process GO:0042981 ISO
    positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 ISO
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP
    defense response to bacterium GO:0042742 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of gene expression GO:0010628 ISO
    cell surface receptor signaling pathway GO:0007166 IMP
    prostaglandin metabolic process GO:0006693 TAS
    positive regulation of neuron apoptotic process GO:0043525 ISO
    defense response GO:0006952 IMP
Subcellular Localization
    cytosol GO:0005829 ISO
    membrane raft GO:0045121 ISO
    Golgi membrane GO:0000139 ISO
    extracellular space GO:0005615 ISO
    protein complex GO:0043234 ISO
    plasma membrane GO:0005886 TAS
    Golgi apparatus GO:0005794 IEA
    cell surface GO:0009986 ISO
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    nucleus GO:0005634 ISO
    intracellular GO:0005622 IMP
    membrane GO:0016020 IEA
    mitochondrion GO:0005739 ISO
    synapse GO:0045202 ISO
    axon GO:0030424 ISO
 Experiment description of studies that identified Tnfrsf1a in exosomes
1
Experiment ID 262
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70|HSP90
EV Cytosolic markers
CD63|CD9|
EV Membrane markers
EV Negative markers
Y
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Microarray
 Protein-protein interactions for Tnfrsf1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnfrsf1a is involved
PathwayEvidenceSource
TNF signaling IEA Reactome
TNFR1-mediated proapoptotic signaling IEA Reactome





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