Gene description for Prdm1
Gene name PR domain containing 1, with ZNF domain
Gene symbol Prdm1
Other names/aliases Blimp-1
Blimp1
PRDI-BF1
ZNFPR1A1
b2b1765Clo
Species Mus musculus
 Database cross references - Prdm1
ExoCarta ExoCarta_12142
Entrez Gene 12142
UniProt Q60636  
 Prdm1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Prdm1
Molecular Function
    mRNA methyltransferase activity GO:0008174 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    protein binding GO:0005515 IPI
    Se-methyltransferase activity GO:0051995 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    methyltransferase activity GO:0008168 IEA
    protein-arginine N-methyltransferase activity GO:0016274 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    trimethylamine methyltransferase activity GO:0043834 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    S-methyltransferase activity GO:0008172 IEA
    C-methyltransferase activity GO:0008169 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    DNA binding GO:0003677 IEA
    N-methyltransferase activity GO:0008170 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    RNA methyltransferase activity GO:0008173 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    P-methyltransferase activity GO:0051994 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 ISO
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    histone deacetylase binding GO:0042826 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    monomethylamine methyltransferase activity GO:0043852 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein methyltransferase activity GO:0008276 IEA
    sequence-specific DNA binding GO:0043565 IDA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    lysine N-methyltransferase activity GO:0016278 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    metal ion binding GO:0046872 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    O-methyltransferase activity GO:0008171 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    transferase activity GO:0016740 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    nucleic acid binding GO:0003676 IEA
Biological Process
    maternal placenta development GO:0001893 IMP
    in utero embryonic development GO:0001701 IMP
    eye photoreceptor cell development GO:0042462 IMP
    morphogenesis of a branching structure GO:0001763 IMP
    artery morphogenesis GO:0048844 IMP
    sebum secreting cell proliferation GO:1990654 IDA
    positive regulation of B cell differentiation GO:0045579 IDA
    negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 IDA
    intestinal epithelial cell development GO:0060576 IMP
    post-embryonic development GO:0009791 IMP
    transcription from RNA polymerase II promoter GO:0006366 ISO
    methylation GO:0032259 IEA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    embryonic placenta development GO:0001892 IMP
    negative regulation of gene expression GO:0010629 IMP
    germ cell development GO:0007281 IGI
    trophoblast giant cell differentiation GO:0060707 IMP
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of B cell proliferation GO:0030889 IDA
    multicellular organismal development GO:0007275 IEA
    cell fate commitment GO:0045165 IMP
    cellular developmental process GO:0048869 IEA
    regulation of cell proliferation GO:0042127 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Prdm1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Prdm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prdm1 is involved
No pathways found





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