Gene description for Bach2
Gene name BTB and CNC homology 2
Gene symbol Bach2
Other names/aliases E030004N02Rik
Species Mus musculus
 Database cross references - Bach2
ExoCarta ExoCarta_12014
Entrez Gene 12014
UniProt P97303  
 Bach2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Bach2
Molecular Function
    DNA binding GO:0003677 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001206 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Bach2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Bach2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bach2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here