Gene description for CD320
Gene name CD320 molecule
Gene symbol CD320
Other names/aliases 8D6
8D6A
TCBLR
Species Homo sapiens
 Database cross references - CD320
ExoCarta ExoCarta_51293
Vesiclepedia VP_51293
Entrez Gene 51293
HGNC 16692
MIM 606475
UniProt Q9NPF0  
 CD320 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CD320
Molecular Function
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    cobalamin binding GO:0031419 IDA
    cargo receptor activity GO:0038024 EXP
Biological Process
    signal transduction GO:0007165 IEA
    cobalamin transport GO:0015889 IMP
    cobalamin transport GO:0015889 TAS
    vesicle-mediated transport GO:0016192 IEA
    regulation of vitamin metabolic process GO:0030656 IEA
    positive regulation of B cell proliferation GO:0030890 IMP
    B cell costimulation GO:0031296 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified CD320 in exosomes
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CD320
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C19orf18 147685
Affinity Capture-MS Homo sapiens
4 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
5 UBL4A 8266
Affinity Capture-MS Homo sapiens
6 ACVR1 90
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CUL3 8452
Affinity Capture-MS Homo sapiens
9 GPR17 2840
Affinity Capture-MS Homo sapiens
10 SLC22A8 9376
Affinity Capture-MS Homo sapiens
11 MARCH1  
Affinity Capture-MS Homo sapiens
12 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 LTBR 4055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TM4SF18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KCNK18  
Affinity Capture-MS Homo sapiens
16 DAAM2 23500
Affinity Capture-MS Homo sapiens
17 CD4 920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ABCG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NRSN1  
Affinity Capture-MS Homo sapiens
20 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TMEM98 26022
Affinity Capture-MS Homo sapiens
22 CLEC4A  
Affinity Capture-MS Homo sapiens
23 TMX1 81542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 IFNGR1 3459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 DDX58 23586
Affinity Capture-RNA Homo sapiens
26 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ALG6  
Affinity Capture-MS Homo sapiens
29 SLC18A2  
Affinity Capture-MS Homo sapiens
30 KCNE3  
Affinity Capture-MS Homo sapiens
31 C16orf58 64755
Affinity Capture-MS Homo sapiens
32 FBXO2 26232
Affinity Capture-MS Homo sapiens
33 PRDX2 7001
Two-hybrid Homo sapiens
34 UGT1A7 54577
Affinity Capture-MS Homo sapiens
35 FAM8A1 51439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KCNA5  
Affinity Capture-MS Homo sapiens
37 ARRDC3 57561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 KCNA2  
Affinity Capture-MS Homo sapiens
39 XKRX  
Affinity Capture-MS Homo sapiens
40 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 IL2RG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SLC31A1 1317
Affinity Capture-MS Homo sapiens
43 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 UGT3A1  
Affinity Capture-MS Homo sapiens
45 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 C14orf37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RGS9BP  
Affinity Capture-MS Homo sapiens
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