Gene description for TNFRSF10A
Gene name	tumor necrosis factor receptor superfamily, member 10a
Gene symbol	TNFRSF10A
Other names/aliases	APO2 CD261 DR4 TRAILR-1 TRAILR1
Species	Homo sapiens
Database cross references - TNFRSF10A
ExoCarta	ExoCarta_8797
Entrez Gene	8797
HGNC	11904
MIM	603611
UniProt	O00220
TNFRSF10A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Prostate cancer cells	25844599

Gene ontology annotations for TNFRSF10A

Molecular Function     protease binding GO:0002020 IPI     receptor activity GO:0004872 NAS     death receptor activity GO:0005035 TAS     transcription factor binding GO:0008134 IPI     TRAIL binding GO:0045569 NAS     protein binding GO:0005515 IPI Biological Process     necroptotic process GO:0070266 TAS     signal transduction GO:0007165 TAS     cell surface receptor signaling pathway GO:0007166 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 TAS     programmed necrotic cell death GO:0097300 TAS     cellular response to mechanical stimulus GO:0071260 IEP     TRAIL-activated apoptotic signaling pathway GO:0036462 IDA     extrinsic apoptotic signaling pathway GO:0097191 TAS     activation of NF-kappaB-inducing kinase activity GO:0007250 NAS     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 TAS     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 NAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     programmed cell death GO:0012501 TAS     apoptotic process GO:0006915 TAS     regulation of necrotic cell death GO:0010939 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS Subcellular Localization     integral component of membrane GO:0016021 IC     plasma membrane GO:0005886 TAS     intracellular GO:0005622 NAS     cell surface GO:0009986 IDA