Gene description for ERMP1
Gene name endoplasmic reticulum metallopeptidase 1
Gene symbol ERMP1
Other names/aliases FXNA
KIAA1815
bA207C16.3
Species Homo sapiens
 Database cross references - ERMP1
ExoCarta ExoCarta_79956
Vesiclepedia VP_79956
Entrez Gene 79956
HGNC 23703
MIM 611156
UniProt Q7Z2K6  
 ERMP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ERMP1
Molecular Function
    protein binding GO:0005515 IPI
    metalloexopeptidase activity GO:0008235 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    proteolysis GO:0006508 IBA
    endoplasmic reticulum unfolded protein response GO:0030968 IMP
    cellular response to oxidative stress GO:0034599 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 HDA
 Experiment description of studies that identified ERMP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ERMP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 GPM6A 2823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ISG15 9636
Affinity Capture-MS Homo sapiens
5 CHRNA4  
Affinity Capture-MS Homo sapiens
6 TSPAN15 23555
Affinity Capture-MS Homo sapiens
7 RXFP1  
Affinity Capture-MS Homo sapiens
8 OR10H2  
Affinity Capture-MS Homo sapiens
9 SLC39A4 55630
Affinity Capture-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 HPN  
Affinity Capture-MS Homo sapiens
12 GPC1 2817
Affinity Capture-MS Homo sapiens
13 ART1 417
Affinity Capture-MS Homo sapiens
14 PLD4  
Affinity Capture-MS Homo sapiens
15 TYROBP  
Affinity Capture-MS Homo sapiens
16 Ktn1  
Affinity Capture-MS Mus musculus
17 SLC31A2  
Affinity Capture-MS Homo sapiens
18 FFAR1  
Affinity Capture-MS Homo sapiens
19 TM2D3  
Affinity Capture-MS Homo sapiens
20 ASIC1  
Affinity Capture-MS Homo sapiens
21 C4orf3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TM9SF4 9777
Co-fractionation Homo sapiens
23 GPRC5B 51704
Affinity Capture-MS Homo sapiens
24 ST8SIA5  
Affinity Capture-MS Homo sapiens
25 ATP2A3 489
Affinity Capture-MS Homo sapiens
26 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 C3orf52  
Affinity Capture-MS Homo sapiens
28 CCDC47 57003
Affinity Capture-MS Homo sapiens
29 YWHAH 7533
Affinity Capture-MS Homo sapiens
30 CA14 23632
Affinity Capture-MS Homo sapiens
31 GPR17 2840
Affinity Capture-MS Homo sapiens
32 KCNK1  
Affinity Capture-MS Homo sapiens
33 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 STAT5A 6776
Affinity Capture-MS Homo sapiens
35 HS2ST1 9653
Affinity Capture-MS Homo sapiens
36 P2RY8  
Affinity Capture-MS Homo sapiens
37 SLC5A4  
Affinity Capture-MS Homo sapiens
38 GPR182  
Affinity Capture-MS Homo sapiens
39 NUP35 129401
Proximity Label-MS Homo sapiens
40 RPA4  
Proximity Label-MS Homo sapiens
41 UPK1A 11045
Affinity Capture-MS Homo sapiens
42 GPR173  
Affinity Capture-MS Homo sapiens
43 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 Rab5c 19345
Affinity Capture-MS Mus musculus
47 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CNGA4  
Affinity Capture-MS Homo sapiens
49 TTYH1  
Affinity Capture-MS Homo sapiens
50 ZDHHC12  
Affinity Capture-MS Homo sapiens
51 MCOLN3  
Affinity Capture-MS Homo sapiens
52 Bmpr1a  
Affinity Capture-MS Mus musculus
53 ASIC2  
Affinity Capture-MS Homo sapiens
54 CRELD1 78987
Affinity Capture-MS Homo sapiens
55 P2RY2 5029
Affinity Capture-MS Homo sapiens
56 NCEH1 57552
Affinity Capture-MS Homo sapiens
57 NIPAL1  
Affinity Capture-MS Homo sapiens
58 LPAR1 1902
Affinity Capture-MS Homo sapiens
59 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
60 CHRNB4  
Affinity Capture-MS Homo sapiens
61 PCDH10 57575
Affinity Capture-MS Homo sapiens
62 RPA3 6119
Proximity Label-MS Homo sapiens
63 ACKR2  
Affinity Capture-MS Homo sapiens
64 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ENTPD2 954
Affinity Capture-MS Homo sapiens
66 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 ISLR 3671
Affinity Capture-MS Homo sapiens
68 RNF185  
Affinity Capture-MS Homo sapiens
69 LMNA 4000
Proximity Label-MS Homo sapiens
70 KCNK16  
Affinity Capture-MS Homo sapiens
71 CDH13 1012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 GABRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 SIDT2 51092
Affinity Capture-MS Homo sapiens
74 GP9 2815
Affinity Capture-MS Homo sapiens
75 PGRMC1 10857
Affinity Capture-MS Homo sapiens
76 LRRC55  
Affinity Capture-MS Homo sapiens
77 CLEC2D  
Affinity Capture-MS Homo sapiens
78 CD1A 909
Affinity Capture-MS Homo sapiens
79 SCGB3A1 92304
Affinity Capture-MS Homo sapiens
80 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
81 PTDSS1 9791
Affinity Capture-MS Homo sapiens
82 OR2G6  
Affinity Capture-MS Homo sapiens
83 SCN4A  
Affinity Capture-MS Homo sapiens
84 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ATP6V0C 527
Affinity Capture-MS Homo sapiens
86 TEFM  
Affinity Capture-MS Homo sapiens
87 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 LPAR2 9170
Affinity Capture-MS Homo sapiens
90 VIPR1  
Affinity Capture-MS Homo sapiens
91 ADGRE5 976
Affinity Capture-MS Homo sapiens
92 CCR6  
Affinity Capture-MS Homo sapiens
93 ALOX5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 OR1D4  
Affinity Capture-MS Homo sapiens
95 FPR2  
Affinity Capture-MS Homo sapiens
96 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERMP1 is involved
No pathways found





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