Gene description for ART1
Gene name ADP-ribosyltransferase 1
Gene symbol ART1
Other names/aliases ART2
ARTC1
CD296
RT6
Species Homo sapiens
 Database cross references - ART1
ExoCarta ExoCarta_417
Vesiclepedia VP_417
Entrez Gene 417
HGNC 723
MIM 601625
UniProt P52961  
 ART1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ART1
Molecular Function
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IBA
    nucleotidyltransferase activity GO:0016779 IEA
    NAD+-protein-arginine ADP-ribosyltransferase activity GO:0106274 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IEA
    sarcoplasmic reticulum membrane GO:0033017 IEA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified ART1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ART1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Affinity Capture-MS Homo sapiens
2 SIRT2 22933
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 IMPDH1 3614
Affinity Capture-MS Homo sapiens
5 ERMP1 79956
Affinity Capture-MS Homo sapiens
6 OR52N5  
Affinity Capture-MS Homo sapiens
7 GHITM 27069
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ART1 is involved
PathwayEvidenceSource
Alpha-defensins TAS Reactome
Antimicrobial peptides TAS Reactome
Defensins TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome





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