Gene description for ART1
Gene name ADP-ribosyltransferase 1
Gene symbol ART1
Other names/aliases ART2
ARTC1
CD296
RT6
Species Homo sapiens
 Database cross references - ART1
ExoCarta ExoCarta_417
Entrez Gene 417
HGNC 723
MIM 601625
UniProt P52961  
 ART1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ART1
Molecular Function
    NAD+ ADP-ribosyltransferase activity GO:0003950 IEA
    NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0003956 IEA
Biological Process
    protein ADP-ribosylation GO:0006471 IEA
    innate immune response GO:0045087 TAS
Subcellular Localization
    cell surface GO:0009986 IEA
    anchored component of membrane GO:0031225 IEA
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    sarcoplasmic reticulum membrane GO:0033017 IEA
 Experiment description of studies that identified ART1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ART1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDGFB  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which ART1 is involved
PathwayEvidenceSource
Alpha-defensins TAS Reactome





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