Gene description for IMPDH1
Gene name IMP (inosine 5'-monophosphate) dehydrogenase 1
Gene symbol IMPDH1
Other names/aliases IMPD
IMPD1
IMPDH-I
LCA11
RP10
sWSS2608
Species Homo sapiens
 Database cross references - IMPDH1
ExoCarta ExoCarta_3614
Entrez Gene 3614
HGNC 6052
MIM 146690
UniProt P20839  
 IMPDH1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for IMPDH1
Molecular Function
    DNA binding GO:0003677 IDA
    nucleic acid binding GO:0003676 IDA
    nucleotide binding GO:0000166 IEA
    IMP dehydrogenase activity GO:0003938 IEA
    RNA binding GO:0003723 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    GMP biosynthetic process GO:0006177 IEA
    lymphocyte proliferation GO:0046651 IEA
    purine nucleobase metabolic process GO:0006144 TAS
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    purine ribonucleoside monophosphate biosynthetic process GO:0009168 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cell junction GO:0030054 IDA
 Experiment description of studies that identified IMPDH1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IMPDH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IMPDH1 is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis TAS Reactome





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