Gene description for SLC25A32
Gene name solute carrier family 25 (mitochondrial folate carrier), member 32
Gene symbol SLC25A32
Other names/aliases MFT
MFTC
Species Homo sapiens
 Database cross references - SLC25A32
ExoCarta ExoCarta_81034
Entrez Gene 81034
HGNC 29683
MIM 610815
UniProt Q9H2D1  
 SLC25A32 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SLC25A32
Molecular Function
    folic acid transporter activity GO:0008517 NAS
Biological Process
    mitochondrial transport GO:0006839 IEA
    folic acid transport GO:0015884 NAS
    vitamin metabolic process GO:0006766 TAS
    folic acid metabolic process GO:0046655 TAS
    small molecule metabolic process GO:0044281 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC25A32 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SLC25A32
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC25A32 is involved
PathwayEvidenceSource
Metabolism of folate and pterines TAS Reactome





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