Gene description for PDXP
Gene name pyridoxal (pyridoxine, vitamin B6) phosphatase
Gene symbol PDXP
Other names/aliases CIN
PLP
dJ37E16.5
Species Homo sapiens
 Database cross references - PDXP
ExoCarta ExoCarta_57026
Entrez Gene 57026
HGNC 30259
MIM 609246
UniProt Q96GD0  
 PDXP identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PDXP
Molecular Function
    pyridoxal phosphatase activity GO:0033883 ISS
    protein binding GO:0005515 IPI
    heat shock protein binding GO:0031072 IDA
    phosphoprotein phosphatase activity GO:0004721 IDA
    phosphoserine phosphatase activity GO:0004647 IEA
    magnesium ion binding GO:0000287 ISS
Biological Process
    regulation of cytokinesis GO:0032465 IMP
    positive regulation of actin filament depolymerization GO:0030836 IMP
    actin rod assembly GO:0031247 IMP
    pyridoxal phosphate catabolic process GO:0032361 ISS
    cellular response to ATP GO:0071318 IDA
    regulation of mitotic nuclear division GO:0007088 IMP
    protein dephosphorylation GO:0006470 IDA
Subcellular Localization
    cleavage furrow GO:0032154 IDA
    contractile ring GO:0070938 IDA
    lamellipodium GO:0030027 IDA
    actin cytoskeleton GO:0015629 IDA
    midbody GO:0030496 IDA
    extracellular exosome GO:0070062 IDA
    ruffle membrane GO:0032587 IDA
    plasma membrane GO:0005886 IDA
    lamellipodium membrane GO:0031258 IEA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PDXP in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PDXP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDXP is involved
No pathways found





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