Gene description for MED23
Gene name mediator complex subunit 23
Gene symbol MED23
Other names/aliases ARC130
CRSP130
CRSP133
CRSP3
DRIP130
MRT18
SUR-2
SUR2
Species Homo sapiens
 Database cross references - MED23
ExoCarta ExoCarta_9439
Entrez Gene 9439
HGNC 2372
MIM 605042
UniProt Q9ULK4  
 MED23 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MED23
Molecular Function
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 TAS
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    gene expression GO:0010467 TAS
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    transcription factor complex GO:0005667 IDA
    mediator complex GO:0016592 IEA
 Experiment description of studies that identified MED23 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MED23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MED9  
Affinity Capture-MS Homo sapiens
2 MED29  
Affinity Capture-MS Homo sapiens
3 ELF3 1999
Invitro Homo sapiens
4 NCOA6  
Affinity Capture-Western Homo sapiens
5 BRCA1 672
Affinity Capture-MS Homo sapiens
6 MED10  
Affinity Capture-MS Homo sapiens
7 CDK8  
Affinity Capture-Western Homo sapiens
8 CEBPB  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 MED17  
Affinity Capture-MS Homo sapiens
10 MED19  
Affinity Capture-MS Homo sapiens
11 MED28  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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