Gene description for NOTCH1
Gene name	notch 1
Gene symbol	NOTCH1
Other names/aliases	AOS5 AOVD1 TAN1 hN1
Species	Homo sapiens
Database cross references - NOTCH1
ExoCarta	ExoCarta_4851
Entrez Gene	4851
HGNC	7881
MIM	190198
UniProt	P46531
NOTCH1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	19837982
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for NOTCH1

Molecular Function     protein binding GO:0005515 IPI     calcium ion binding GO:0005509 IEA     chromatin DNA binding GO:0031490 IEA     enzyme inhibitor activity GO:0004857 ISS     sequence-specific DNA binding transcription factor activity GO:0003700 IEA     core promoter binding GO:0001047 ISS     sequence-specific DNA binding GO:0043565 IEA     RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription GO:0001190 ISS     enzyme binding GO:0019899 ISS     receptor activity GO:0004872 IEA Biological Process     endocardial cushion morphogenesis GO:0003203 ISS     positive regulation of transcription, DNA-templated GO:0045893 ISS     forebrain development GO:0030900 IEA     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA     glomerular mesangial cell development GO:0072144 IEA     spermatogenesis GO:0007283 IEA     negative regulation of neurogenesis GO:0050768 ISS     prostate gland epithelium morphogenesis GO:0060740 IEA     cardiac epithelial to mesenchymal transition GO:0060317 ISS     positive regulation of cell migration GO:0030335 ISS     positive regulation of cell proliferation GO:0008284 IMP     endoderm development GO:0007492 IEA     negative regulation of ossification GO:0030279 ISS     astrocyte differentiation GO:0048708 IEA     regulation of somitogenesis GO:0014807 IEA     hair follicle morphogenesis GO:0031069 IEA     inflammatory response to antigenic stimulus GO:0002437 IEA     distal tubule development GO:0072017 IEA     regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 IEA     branching morphogenesis of an epithelial tube GO:0048754 IEA     positive regulation of cardiac muscle cell proliferation GO:0060045 ISS     coronary artery morphogenesis GO:0060982 ISS     lung development GO:0030324 IEA     Notch receptor processing GO:0007220 TAS     cardiac right ventricle formation GO:0003219 IEA     negative regulation of BMP signaling pathway GO:0030514 ISS     regulation of extracellular matrix assembly GO:1901201 ISS     axonogenesis GO:0007409 IEA     negative regulation of calcium ion-dependent exocytosis GO:0045955 IEA     positive regulation of epithelial cell proliferation GO:0050679 IEA     tissue regeneration GO:0042246 IEA     Notch signaling involved in heart development GO:0061314 IMP     endocardium morphogenesis GO:0003160 ISS     left/right axis specification GO:0070986 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     response to lipopolysaccharide GO:0032496 IEA     mitral valve formation GO:0003192 IMP     negative regulation of oligodendrocyte differentiation GO:0048715 ISS     endocardial cell differentiation GO:0060956 ISS     oligodendrocyte differentiation GO:0048709 IEA     tube formation GO:0035148 IMP     compartment pattern specification GO:0007386 IEA     positive regulation of JAK-STAT cascade GO:0046427 ISS     arterial endothelial cell differentiation GO:0060842 ISS     interleukin-4 secretion GO:0072602 IEA     cardiac septum morphogenesis GO:0060411 ISS     cardiac ventricle morphogenesis GO:0003208 ISS     atrioventricular valve morphogenesis GO:0003181 ISS     cardiac vascular smooth muscle cell development GO:0060948 ISS     response to corticosteroid GO:0031960 IEA     cardiac chamber formation GO:0003207 ISS     negative regulation of osteoblast differentiation GO:0045668 ISS     cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA     growth involved in heart morphogenesis GO:0003241 ISS     apoptotic process involved in embryonic digit morphogenesis GO:1902263 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     cardiac muscle cell proliferation GO:0060038 IEA     auditory receptor cell fate commitment GO:0009912 IEA     regulation of transcription, DNA-templated GO:0006355 TAS     atrioventricular node development GO:0003162 IEA     cell fate specification GO:0001708 IEA     foregut morphogenesis GO:0007440 IEA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     collecting duct development GO:0072044 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 IMP     keratinocyte differentiation GO:0030216 IEA     coronary vein morphogenesis GO:0003169 ISS     negative regulation of transcription, DNA-templated GO:0045892 ISS     negative regulation of cell proliferation GO:0008285 IDA     ventricular septum morphogenesis GO:0060412 IMP     gene expression GO:0010467 TAS     negative regulation of glial cell proliferation GO:0060253 ISS     positive regulation of astrocyte differentiation GO:0048711 ISS     positive regulation of apoptotic process GO:0043065 IEA     pericardium morphogenesis GO:0003344 ISS     positive regulation of keratinocyte differentiation GO:0045618 IEA     cardiac right atrium morphogenesis GO:0003213 ISS     determination of left/right symmetry GO:0007368 ISS     aortic valve morphogenesis GO:0003180 IMP     negative regulation of catalytic activity GO:0043086 ISS     neural tube development GO:0021915 IEA     cardiac muscle tissue morphogenesis GO:0055008 ISS     negative regulation of endothelial cell chemotaxis GO:2001027 IDA     cilium morphogenesis GO:0060271 ISS     immune response GO:0006955 NAS     negative regulation of stem cell differentiation GO:2000737 IMP     epithelial to mesenchymal transition GO:0001837 ISS     Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation GO:0003270 IEA     positive regulation of transcription of Notch receptor target GO:0007221 ISS     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     negative regulation of anoikis GO:2000811 IMP     organ regeneration GO:0031100 IEA     heart development GO:0007507 IMP     heart trabecula morphogenesis GO:0061384 ISS     epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 ISS     negative regulation of myotube differentiation GO:0010832 ISS     vasculogenesis involved in coronary vascular morphogenesis GO:0060979 ISS     venous endothelial cell differentiation GO:0060843 ISS     liver development GO:0001889 IEA     regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0003256 ISS     negative regulation of cell-substrate adhesion GO:0010812 IDA     humoral immune response GO:0006959 IEA     ventricular trabecula myocardium morphogenesis GO:0003222 ISS     mesenchymal cell development GO:0014031 ISS     heart looping GO:0001947 ISS     negative regulation of photoreceptor cell differentiation GO:0046533 IEA     negative regulation of pro-B cell differentiation GO:2000974 ISS     pulmonary valve morphogenesis GO:0003184 IMP     cardiac left ventricle morphogenesis GO:0003214 ISS     embryonic hindlimb morphogenesis GO:0035116 IEA     positive regulation of BMP signaling pathway GO:0030513 ISS     positive regulation of endothelial cell differentiation GO:0045603 IEA     in utero embryonic development GO:0001701 IEA     somatic stem cell division GO:0048103 IEA     cellular response to follicle-stimulating hormone stimulus GO:0071372 IDA     sprouting angiogenesis GO:0002040 IEA     skeletal muscle cell differentiation GO:0035914 IEA     endocardium development GO:0003157 ISS     cardiac atrium morphogenesis GO:0003209 ISS     neuronal stem cell maintenance GO:0097150 IEP     Notch signaling pathway GO:0007219 TAS     positive regulation of neuroblast proliferation GO:0002052 IEA     secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 IEA     negative regulation of myoblast differentiation GO:0045662 IMP     cell migration involved in endocardial cushion formation GO:0003273 ISS     positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 ISS     response to muramyl dipeptide GO:0032495 IEA     cell differentiation in spinal cord GO:0021515 IEA Subcellular Localization     plasma membrane GO:0005886 TAS     cytosol GO:0005829 TAS     receptor complex GO:0043235 IDA     extracellular region GO:0005576 TAS     integral component of membrane GO:0016021 IEA     nucleus GO:0005634 TAS     cell surface GO:0009986 IEA     acrosomal vesicle GO:0001669 IEA     MAML1-RBP-Jkappa- ICN1 complex GO:0002193 IDA     Golgi membrane GO:0000139 TAS     nucleoplasm GO:0005654 TAS     endoplasmic reticulum membrane GO:0005789 TAS