Gene description for WWTR1
Gene name	WW domain containing transcription regulator 1
Gene symbol	WWTR1
Other names/aliases	TAZ
Species	Homo sapiens
Database cross references - WWTR1
ExoCarta	ExoCarta_25937
Entrez Gene	25937
HGNC	24042
MIM	607392
UniProt	Q9GZV5
WWTR1 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for WWTR1

Molecular Function     protein binding GO:0005515 IPI     transcription coactivator activity GO:0003713 NAS     protein homodimerization activity GO:0042803 IEA     transcription corepressor activity GO:0003714 IEA Biological Process     negative regulation of protein phosphorylation GO:0001933 IMP     regulation of SMAD protein import into nucleus GO:0060390 IDA     protein ubiquitination GO:0016567 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     negative regulation of catenin import into nucleus GO:0035414 IMP     osteoblast differentiation GO:0001649 IEA     cilium morphogenesis GO:0060271 IEA     stem cell division GO:0017145 IDA     positive regulation of epithelial to mesenchymal transition GO:0010718 IDA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IEA     negative regulation of protein kinase activity GO:0006469 IMP     hippo signaling GO:0035329 TAS     gene expression GO:0010467 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     glomerulus development GO:0032835 IEA     regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 IEA     kidney morphogenesis GO:0060993 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     negative regulation of fat cell differentiation GO:0045599 IEA     mesenchymal cell differentiation GO:0048762 IEA     positive regulation of cell proliferation GO:0008284 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 IMP     multicellular organism growth GO:0035264 IEA     transcription, DNA-templated GO:0006351 TAS     regulation of transcription, DNA-templated GO:0006355 NAS Subcellular Localization     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS     nucleus GO:0005634 NAS     cytoplasm GO:0005737 IDA     transcription factor complex GO:0005667 IEA