Gene description for USP11
Gene name ubiquitin specific peptidase 11
Gene symbol USP11
Other names/aliases UHX1
Species Homo sapiens
 Database cross references - USP11
ExoCarta ExoCarta_8237
Entrez Gene 8237
HGNC 12609
MIM 300050
UniProt P51784  
 USP11 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for USP11
Molecular Function
    protein binding GO:0005515 IPI
    cysteine-type endopeptidase activity GO:0004197 TAS
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein deubiquitination GO:0016579 IDA
    regulation of proteasomal protein catabolic process GO:0061136 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified USP11 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WBP5  
Affinity Capture-MS Homo sapiens
2 RANBP9 10048
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 TCEAL1  
Affinity Capture-MS Homo sapiens
4 CIAO1 9391
Affinity Capture-MS Homo sapiens
5 RELB  
Affinity Capture-MS Homo sapiens
6 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which USP11 is involved
PathwayEvidenceSource
Association of TriC/CCT with target proteins during biosynthesis TAS Reactome





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