Gene description for NFE2L2
Gene name	nuclear factor, erythroid 2-like 2
Gene symbol	NFE2L2
Other names/aliases	NRF2
Species	Homo sapiens
Database cross references - NFE2L2
ExoCarta	ExoCarta_4780
Vesiclepedia	VP_4780
Entrez Gene	4780
HGNC	7782
MIM	600492
UniProt	Q16236
NFE2L2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for NFE2L2

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     transcription cis-regulatory region binding GO:0000976 TAS     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     transcription coregulator binding GO:0001221 IEA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP     DNA binding GO:0003677 IDA     DNA-binding transcription factor activity GO:0003700 IDA     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IPI     ubiquitin protein ligase binding GO:0031625 IPI     sequence-specific DNA binding GO:0043565 IDA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     molecular condensate scaffold activity GO:0140693 IDA Biological Process     response to ischemia GO:0002931 IEA     regulation of transcription by RNA polymerase II GO:0006357 IBA     regulation of transcription by RNA polymerase II GO:0006357 NAS     inflammatory response GO:0006954 IEA     response to oxidative stress GO:0006979 IDA     proteasomal ubiquitin-independent protein catabolic process GO:0010499 IDA     positive regulation of gene expression GO:0010628 IMP     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IEA     positive regulation of neuron projection development GO:0010976 IEA     protein ubiquitination GO:0016567 IDA     positive regulation of blood coagulation GO:0030194 IEA     endoplasmic reticulum unfolded protein response GO:0030968 ISS     cellular response to oxidative stress GO:0034599 IBA     cellular response to oxidative stress GO:0034599 IDA     cellular response to oxidative stress GO:0034599 ISS     cellular response to oxidative stress GO:0034599 NAS     cellular response to oxidative stress GO:0034599 TAS     PERK-mediated unfolded protein response GO:0036499 ISS     PERK-mediated unfolded protein response GO:0036499 TAS     cellular response to glucose starvation GO:0042149 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     positive regulation of blood vessel endothelial cell migration GO:0043536 IEA     regulation of innate immune response GO:0045088 ISS     cell redox homeostasis GO:0045454 IMP     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     regulation of embryonic development GO:0045995 IEA     aflatoxin catabolic process GO:0046223 IEA     positive regulation of D-glucose import GO:0046326 IEA     cellular response to methionine GO:0061431 IEA     cellular response to hydrogen peroxide GO:0070301 IGI     cellular response to hydrogen peroxide GO:0070301 IMP     cellular response to copper ion GO:0071280 IEA     cellular response to tumor necrosis factor GO:0071356 IMP     cellular response to hypoxia GO:0071456 IMP     cellular response to xenobiotic stimulus GO:0071466 IEA     cellular response to fluid shear stress GO:0071498 IDA     cellular response to laminar fluid shear stress GO:0071499 IMP     reactive oxygen species metabolic process GO:0072593 IEA     negative regulation of ferroptosis GO:0110076 IMP     integrated stress response signaling GO:0140467 NAS     negative regulation of cellular response to hypoxia GO:1900038 IEA     regulation of cellular response to oxidative stress GO:1900407 EXP     negative regulation of hematopoietic stem cell differentiation GO:1902037 IEA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IMP     positive regulation of glutathione biosynthetic process GO:1903788 IEA     positive regulation of ERAD pathway GO:1904294 TAS     cellular response to angiotensin GO:1904385 IEA     negative regulation of vascular associated smooth muscle cell migration GO:1904753 IEA     positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 TAS     regulation of removal of superoxide radicals GO:2000121 IEA     negative regulation of endothelial cell apoptotic process GO:2000352 IMP     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA Subcellular Localization     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     Golgi apparatus GO:0005794 IDA     centrosome GO:0005813 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     mediator complex GO:0016592 EXP     protein-DNA complex GO:0032993 ISS     RNA polymerase II transcription regulator complex GO:0090575 IPI