Gene description for MAP2K1
Gene name	mitogen-activated protein kinase kinase 1
Gene symbol	MAP2K1
Other names/aliases	CFC3 MAPKK1 MEK1 MKK1 PRKMK1
Species	Homo sapiens
Database cross references - MAP2K1
ExoCarta	ExoCarta_5604
Entrez Gene	5604
HGNC	6840
MIM	176872
UniProt	Q02750
MAP2K1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for MAP2K1

Molecular Function     protein C-terminus binding GO:0008022 IDA     protein serine/threonine kinase activity GO:0004674 TAS     protein binding GO:0005515 IPI     protein kinase activity GO:0004672 TAS     Ras GTPase binding GO:0017016 IEA     MAP kinase kinase activity GO:0004708 IDA     protein serine/threonine/tyrosine kinase activity GO:0004712 TAS     protein serine/threonine kinase activator activity GO:0043539 IDA     ATP binding GO:0005524 IEA     receptor signaling protein tyrosine phosphatase activity GO:0004728 IEA     protein tyrosine kinase activity GO:0004713 IEA     protein N-terminus binding GO:0047485 IDA     mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA Biological Process     labyrinthine layer development GO:0060711 IEA     toll-like receptor signaling pathway GO:0002224 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     positive regulation of gene expression GO:0010628 IMP     regulation of vascular smooth muscle contraction GO:0003056 IEA     regulation of early endosome to late endosome transport GO:2000641 TAS     axon guidance GO:0007411 TAS     negative regulation of homotypic cell-cell adhesion GO:0034111 IEA     cell cycle arrest GO:0007050 IMP     regulation of Golgi inheritance GO:0090170 TAS     innate immune response GO:0045087 TAS     chemotaxis GO:0006935 TAS     response to glucocorticoid GO:0051384 IEA     positive regulation of protein serine/threonine kinase activity GO:0071902 IDA     toll-like receptor 10 signaling pathway GO:0034166 TAS     vesicle transport along microtubule GO:0047496 IEA     signal transduction GO:0007165 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     movement of cell or subcellular component GO:0006928 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     stress-activated MAPK cascade GO:0051403 TAS     insulin receptor signaling pathway GO:0008286 TAS     Ras protein signal transduction GO:0007265 TAS     positive regulation of cell migration GO:0030335 IEA     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     small GTPase mediated signal transduction GO:0007264 TAS     positive regulation of cell differentiation GO:0045597 IEA     Golgi inheritance GO:0048313 IEA     toll-like receptor 4 signaling pathway GO:0034142 TAS     response to oxidative stress GO:0006979 IEA     cellular senescence GO:0090398 IMP     positive regulation of Ras protein signal transduction GO:0046579 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     MAPK cascade GO:0000165 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     activation of MAPKK activity GO:0000186 TAS     neuron differentiation GO:0030182 IBA     activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP     negative regulation of cell proliferation GO:0008285 IDA     activation of MAPK activity GO:0000187 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     cell motility GO:0048870 IEA     positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     keratinocyte differentiation GO:0030216 IEA     response to axon injury GO:0048678 IEA     protein heterooligomerization GO:0051291 IEA     melanosome transport GO:0032402 IEA     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     mitotic nuclear division GO:0007067 IEA     regulation of stress-activated MAPK cascade GO:0032872 TAS     cell proliferation GO:0008283 IEA     placenta blood vessel development GO:0060674 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS Subcellular Localization     microtubule GO:0005874 IEA     extracellular exosome GO:0070062 IDA     dendrite cytoplasm GO:0032839 IEA     perinuclear region of cytoplasm GO:0048471 IEA     axon GO:0030424 IEA     focal adhesion GO:0005925 TAS     endoplasmic reticulum GO:0005783 IDA     nucleus GO:0005634 TAS     cytosol GO:0005829 TAS     early endosome GO:0005769 TAS     intracellular GO:0005622 IBA     microtubule organizing center GO:0005815 IEA     Golgi apparatus GO:0005794 TAS     cell cortex GO:0005938 IEA     late endosome GO:0005770 TAS     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 TAS     perikaryon GO:0043204 IEA     plasma membrane GO:0005886 IDA