Gene description for DNAH1
Gene name dynein, axonemal, heavy chain 1
Gene symbol DNAH1
Other names/aliases DNAHC1
HDHC7
HL-11
HL11
HSRF-1
XLHSRF-1
Species Homo sapiens
 Database cross references - DNAH1
ExoCarta ExoCarta_25981
Vesiclepedia VP_25981
Entrez Gene 25981
HGNC 2940
MIM 603332
UniProt Q9P2D7  
 DNAH1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DNAH1
Molecular Function
    microtubule motor activity GO:0003777 NAS
    ATP binding GO:0005524 IEA
    minus-end-directed microtubule motor activity GO:0008569 IBA
    dynein intermediate chain binding GO:0045505 IBA
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    epithelial cilium movement involved in extracellular fluid movement GO:0003351 IEA
    sperm axoneme assembly GO:0007288 IMP
    flagellated sperm motility GO:0030317 IBA
    flagellated sperm motility GO:0030317 IMP
    flagellated sperm motility GO:0030317 IMP
    inner dynein arm assembly GO:0036159 IDA
    cilium-dependent cell motility GO:0060285 NAS
Subcellular Localization
    extracellular region GO:0005576 IEA
    axonemal dynein complex GO:0005858 NAS
    microtubule GO:0005874 IEA
    axoneme GO:0005930 IMP
    dynein complex GO:0030286 IBA
    sperm flagellum GO:0036126 IBA
    sperm flagellum GO:0036126 IDA
    inner dynein arm GO:0036156 IDA
 Experiment description of studies that identified DNAH1 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DNAH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
3 OBSL1 23363
Affinity Capture-MS Homo sapiens
4 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
5 YARS 8565
Cross-Linking-MS (XL-MS) Homo sapiens
6 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
7 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
8 MCM2 4171
Cross-Linking-MS (XL-MS) Homo sapiens
9 MAP2K1 5604
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DNAH1 is involved
No pathways found





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