Gene description for HIST1H2BH
Gene name histone cluster 1, H2bh
Gene symbol HIST1H2BH
Other names/aliases H2B/j
H2BFJ
Species Homo sapiens
 Database cross references - HIST1H2BH
ExoCarta ExoCarta_8345
Vesiclepedia VP_8345
Entrez Gene 8345
HGNC 4755
MIM 602806
UniProt Q93079  
 HIST1H2BH identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for HIST1H2BH
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    structural constituent of chromatin GO:0030527 IEA
    ubiquitin-like protein ligase binding GO:0044389 IPI
    protein heterodimerization activity GO:0046982 IEA
    STAT family protein binding GO:0097677 IPI
Biological Process
    nucleosome assembly GO:0006334 NAS
Subcellular Localization
    nucleosome GO:0000786 NAS
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    protein-containing complex GO:0032991 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST1H2BH in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
5
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
6
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
12
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for HIST1H2BH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
2 SMC3 9126
Cross-Linking-MS (XL-MS) Homo sapiens
3 SPRTN  
Affinity Capture-MS Homo sapiens
4 OSBPL9 114883
Cross-Linking-MS (XL-MS) Homo sapiens
5 ZBTB11  
Cross-Linking-MS (XL-MS) Homo sapiens
6 EEF1G 1937
Cross-Linking-MS (XL-MS) Homo sapiens
7 PDAP1 11333
Cross-Linking-MS (XL-MS) Homo sapiens
8 ABCA13  
Cross-Linking-MS (XL-MS) Homo sapiens
9 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
10 SSB 6741
Cross-Linking-MS (XL-MS) Homo sapiens
11 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
12 BTF3 689
Affinity Capture-MS Homo sapiens
13 ABCF1 23
Cross-Linking-MS (XL-MS) Homo sapiens
14 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
15 ARL6IP4  
Cross-Linking-MS (XL-MS) Homo sapiens
16 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
17 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
18 KARS 3735
Cross-Linking-MS (XL-MS) Homo sapiens
19 BASP1 10409
Cross-Linking-MS (XL-MS) Homo sapiens
20 RPS3 6188
Cross-Linking-MS (XL-MS) Homo sapiens
21 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
22 SPECC1L 23384
Cross-Linking-MS (XL-MS) Homo sapiens
23 MCM2 4171
Affinity Capture-MS Homo sapiens
24 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
25 PHLDA2 7262
Cross-Linking-MS (XL-MS) Homo sapiens
26 SPAG9 9043
Cross-Linking-MS (XL-MS) Homo sapiens
27 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
28 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
29 C8orf59  
Cross-Linking-MS (XL-MS) Homo sapiens
30 TRO  
Cross-Linking-MS (XL-MS) Homo sapiens
31 MCM6 4175
Cross-Linking-MS (XL-MS) Homo sapiens
32 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
33 ANKRD36 375248
Cross-Linking-MS (XL-MS) Homo sapiens
34 ENPP1 5167
Cross-Linking-MS (XL-MS) Homo sapiens
35 ITGA4 3676
Affinity Capture-MS Homo sapiens
36 ATRX 546
Cross-Linking-MS (XL-MS) Homo sapiens
37 FAF2 23197
Cross-Linking-MS (XL-MS) Homo sapiens
38 ALG5 29880
Cross-Linking-MS (XL-MS) Homo sapiens
39 EEF1A1 1915
Cross-Linking-MS (XL-MS) Homo sapiens
40 PDS5B 23047
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
41 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
42 ZDHHC17 23390
Two-hybrid Homo sapiens
43 CEP350 9857
Cross-Linking-MS (XL-MS) Homo sapiens
44 SCAF1  
Cross-Linking-MS (XL-MS) Homo sapiens
45 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
46 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
47 RPL4 6124
Cross-Linking-MS (XL-MS) Homo sapiens
48 MRPS34 65993
Cross-Linking-MS (XL-MS) Homo sapiens
49 CCDC88C 440193
Cross-Linking-MS (XL-MS) Homo sapiens
50 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
51 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
52 PSMD14 10213
Affinity Capture-MS Homo sapiens
53 NOP2 4839
Cross-Linking-MS (XL-MS) Homo sapiens
54 ABCF2 10061
Cross-Linking-MS (XL-MS) Homo sapiens
55 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
56 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
57 MYH9 4627
Cross-Linking-MS (XL-MS) Homo sapiens
58 KIF5A 3798
Cross-Linking-MS (XL-MS) Homo sapiens
59 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
60 CKAP5 9793
Cross-Linking-MS (XL-MS) Homo sapiens
61 LYRM7  
Cross-Linking-MS (XL-MS) Homo sapiens
62 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
63 HMGA2 8091
Cross-Linking-MS (XL-MS) Homo sapiens
64 SPAG17  
Cross-Linking-MS (XL-MS) Homo sapiens
65 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
66 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
67 SMC1A 8243
Cross-Linking-MS (XL-MS) Homo sapiens
68 MYH10 4628
Cross-Linking-MS (XL-MS) Homo sapiens
69 ENY2 56943
Cross-Linking-MS (XL-MS) Homo sapiens
70 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
71 BRD4 23476
Cross-Linking-MS (XL-MS) Homo sapiens
72 DDX39B 7919
Cross-Linking-MS (XL-MS) Homo sapiens
73 CYLC1 1538
Cross-Linking-MS (XL-MS) Homo sapiens
74 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
75 MRPL2 51069
Cross-Linking-MS (XL-MS) Homo sapiens
76 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
77 RAN 5901
Cross-Linking-MS (XL-MS) Homo sapiens
78 MESDC2 23184
Cross-Linking-MS (XL-MS) Homo sapiens
79 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
80 HMGN1  
Cross-Linking-MS (XL-MS) Homo sapiens
81 DST 667
Cross-Linking-MS (XL-MS) Homo sapiens
82 HNRNPD 3184
Affinity Capture-MS Homo sapiens
83 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
84 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
85 GPC4 2239
Cross-Linking-MS (XL-MS) Homo sapiens
86 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
87 RPL7A 6130
Cross-Linking-MS (XL-MS) Homo sapiens
88 ATL3 25923
Cross-Linking-MS (XL-MS) Homo sapiens
89 HIST2H3C 126961
Cross-Linking-MS (XL-MS) Homo sapiens
90 SMARCA5 8467
Cross-Linking-MS (XL-MS) Homo sapiens
91 PNN 5411
Cross-Linking-MS (XL-MS) Homo sapiens
92 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
93 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
94 RPL21 6144
Cross-Linking-MS (XL-MS) Homo sapiens
95 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
96 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
97 YLPM1 56252
Cross-Linking-MS (XL-MS) Homo sapiens
98 EBNA1BP2 10969
Cross-Linking-MS (XL-MS) Homo sapiens
99 ATAD3C 219293
Cross-Linking-MS (XL-MS) Homo sapiens
100 H1F0 3005
Cross-Linking-MS (XL-MS) Homo sapiens
101 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
102 POLR2A 5430
Cross-Linking-MS (XL-MS) Homo sapiens
103 SS18  
Cross-Linking-MS (XL-MS) Homo sapiens
104 ARFIP1 27236
Cross-Linking-MS (XL-MS) Homo sapiens
105 FSIP2 401024
Cross-Linking-MS (XL-MS) Homo sapiens
106 TOMM70A 9868
Cross-Linking-MS (XL-MS) Homo sapiens
107 PDCD4 27250
Cross-Linking-MS (XL-MS) Homo sapiens
108 GIGYF2 26058
Cross-Linking-MS (XL-MS) Homo sapiens
109 HIST1H1B 3009
Cross-Linking-MS (XL-MS) Homo sapiens
110 MAPK6  
Cross-Linking-MS (XL-MS) Homo sapiens
111 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
112 CEBPZ  
Cross-Linking-MS (XL-MS) Homo sapiens
113 RPS14 6208
Cross-Linking-MS (XL-MS) Homo sapiens
114 DNAH1 25981
Cross-Linking-MS (XL-MS) Homo sapiens
115 KIAA1109 84162
Cross-Linking-MS (XL-MS) Homo sapiens
116 STMN1 3925
Cross-Linking-MS (XL-MS) Homo sapiens
117 PARP4 143
Cross-Linking-MS (XL-MS) Homo sapiens
118 SGTA 6449
Cross-Linking-MS (XL-MS) Homo sapiens
119 VBP1 7411
Cross-Linking-MS (XL-MS) Homo sapiens
120 FBF1  
Cross-Linking-MS (XL-MS) Homo sapiens
121 FSCN1 6624
Cross-Linking-MS (XL-MS) Homo sapiens
122 DLAT 1737
Cross-Linking-MS (XL-MS) Homo sapiens
123 MAP7D2 256714
Cross-Linking-MS (XL-MS) Homo sapiens
124 TAF4 6874
Cross-Linking-MS (XL-MS) Homo sapiens
125 PIN4 5303
Cross-Linking-MS (XL-MS) Homo sapiens
126 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
127 AHSA1 10598
Cross-Linking-MS (XL-MS) Homo sapiens
128 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
129 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
130 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
131 TP53BP2  
Two-hybrid Homo sapiens
132 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
133 PRRC2A 7916
Cross-Linking-MS (XL-MS) Homo sapiens
134 HMGN4  
Cross-Linking-MS (XL-MS) Homo sapiens
135 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
136 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
137 EIF1AX 1964
Cross-Linking-MS (XL-MS) Homo sapiens
138 SUCLG2 8801
Cross-Linking-MS (XL-MS) Homo sapiens
139 MCM5 4174
Affinity Capture-MS Homo sapiens
140 JPH2 57158
Cross-Linking-MS (XL-MS) Homo sapiens
141 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
142 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
143 RPS4X 6191
Cross-Linking-MS (XL-MS) Homo sapiens
144 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
145 SECISBP2L  
Cross-Linking-MS (XL-MS) Homo sapiens
146 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
147 EIF4A3 9775
Cross-Linking-MS (XL-MS) Homo sapiens
148 PRKACA 5566
Cross-Linking-MS (XL-MS) Homo sapiens
149 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
150 EZH2  
Cross-Linking-MS (XL-MS) Homo sapiens
151 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
152 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
153 ACTA2 59
Cross-Linking-MS (XL-MS) Homo sapiens
154 PINK1  
Affinity Capture-MS Homo sapiens
155 FGFR1OP  
Cross-Linking-MS (XL-MS) Homo sapiens
156 SERBP1 26135
Affinity Capture-MS Homo sapiens
157 C9orf72  
Affinity Capture-MS Homo sapiens
158 CASP8AP2  
Cross-Linking-MS (XL-MS) Homo sapiens
159 PGM3 5238
Cross-Linking-MS (XL-MS) Homo sapiens
160 C11orf58  
Cross-Linking-MS (XL-MS) Homo sapiens
161 H1FOO 132243
Cross-Linking-MS (XL-MS) Homo sapiens
162 TIMM44 10469
Cross-Linking-MS (XL-MS) Homo sapiens
163 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
164 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H2BH is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Protein ubiquitination TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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