Gene description for CDK5R2
Gene name cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Gene symbol CDK5R2
Other names/aliases NCK5AI
P39
p39nck5ai
Species Homo sapiens
 Database cross references - CDK5R2
ExoCarta ExoCarta_8941
Entrez Gene 8941
HGNC 1776
MIM 603764
UniProt Q13319  
 CDK5R2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CDK5R2
Molecular Function
    cyclin-dependent protein kinase 5 activator activity GO:0016534 IEA
    lipid binding GO:0008289 IEA
Biological Process
    neuron migration GO:0001764 IEA
    layer formation in cerebral cortex GO:0021819 IEA
    superior olivary nucleus maturation GO:0021722 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    positive regulation of calcium ion-dependent exocytosis GO:0045956 IEA
    cerebellum development GO:0021549 IEA
    hippocampus development GO:0021766 IEA
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
Subcellular Localization
    cyclin-dependent protein kinase 5 holoenzyme complex GO:0016533 IEA
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified CDK5R2 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CDK5R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK5 1020
Invivo Homo sapiens
2 ACTN1 87
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDK5R2 is involved
No pathways found





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