Gene description for TIMM44
Gene name translocase of inner mitochondrial membrane 44 homolog (yeast)
Gene symbol TIMM44
Other names/aliases TIM44
Species Homo sapiens
 Database cross references - TIMM44
ExoCarta ExoCarta_10469
Entrez Gene 10469
HGNC 17316
MIM 605058
UniProt O43615  
 TIMM44 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TIMM44
Molecular Function
    protein binding GO:0005515 IPI
    chaperone binding GO:0051087 IBA
    ATP binding GO:0005524 IEA
    P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0015450 IEA
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    protein targeting to mitochondrion GO:0006626 TAS
    protein import into mitochondrial matrix GO:0030150 IBA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified TIMM44 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TIMM44
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA4 3308
Reconstituted Complex Homo sapiens
2 TIMM44 10469
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ARAF 369
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 TIMM17A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TIMM44 is involved
Mitochondrial protein import TAS Reactome

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